Undergraduate Course: The RNA World/Mammalian Transgenesis & Genome Engineering (MLBI10005)
Course Outline
School |
School of Biological Sciences |
College |
College of Science and Engineering |
Course type |
Standard |
Availability |
Not available to visiting students |
Credit level (Normal year taken) |
SCQF Level 10 (Year 4 Undergraduate) |
Credits |
10 |
Home subject area |
Molecular Biology |
Other subject area |
None |
Course website |
None |
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Course description |
The RNA World:
Recent years have seen a growing awareness of the major role played by RNA molecules and RNA metabolism in biological systems. The course will cover many aspects of the function, transport and evolution of RNA and will highlight the dual roles of RNAs as functional components of cells and major carriers and mediators of genetic information.
Topics:
The RNA world hypothesis for the origins of life. The structure of RNA, RNA-mediated catalysis and splicing. The synthesis, modification, transport and degradation of mRNAs. The roles of these activities in the regulation of gene expression. mRNA localization and its importance for cell and organism polarity. The use of RNAi to analyse gene expression and function. Small RNAs as therapeutic agents.
Mammalian Transgenesis & Genome Engineering:
This Elective Course will provide a greater in-depth knowledge of the technologies presented in the Core Course for introducing genetically engineered modifications into the germ line of mammals. In particular there will be emphasis on discussing recent innovations in the following areas: chromosome engineering; transfer of human and artificial chromosomes into mice; BAC recombineering and transgenesis; conditional gene expression strategies; optimisation and genetic modification of somatic cells for transgenesis by nuclear transfer; and applications of these to functional genomics analysis, biomedical research and biotechnology. |
Entry Requirements
Pre-requisites |
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Co-requisites |
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Prohibited Combinations |
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Other requirements |
None
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Additional Costs |
Notepads |
Course Delivery Information
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Delivery period: 2010/11 Semester 2, Not available to visiting students (SS1)
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WebCT enabled: Yes |
Quota: None |
Location |
Activity |
Description |
Weeks |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
King's Buildings | Lecture | | 1-11 | | | | 09:00 - 10:50 | | King's Buildings | Lecture | | 1-11 | | 09:00 - 10:50 | | | |
First Class |
First class information not currently available |
Additional information |
Tuesday - Mammalian Transgensis & Genome Engineering
Thursday - The RNA World
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Summary of Intended Learning Outcomes
Increased understanding of Biological processes. Detailed learning outcomes will be provided later. |
Assessment Information
Essay (5 points)/Essay (5 points) - Semester 2, Week 6 (February) |
Special Arrangements
Not entered |
Contacts
Course organiser |
Prof Hiro Ohkura
Tel: (0131 6)50 7094
Email: H.Ohkura@ed.ac.uk |
Course secretary |
Miss Donna Wright
Tel: (0131 6)51 7051
Email: Donna.Wright@ed.ac.uk |
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copyright 2010 The University of Edinburgh -
1 September 2010 6:21 am
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