Postgraduate Course: Protein Structure Determination (PGBI11021)
Course Outline
| School |
School of Biological Sciences |
College |
College of Science and Engineering |
| Course type |
Standard |
Availability |
Not available to visiting students |
| Credit level (Normal year taken) |
SCQF Level 11 (Postgraduate) |
Credits |
10 |
| Home subject area |
Postgraduate |
Other subject area |
None |
| Course website |
None |
|
|
| Course description |
This course will provide a hands-on approach in protein structure determination. Students will be given a data set of X-ray diffraction images and the structure of a protein will be determined by molecular replacement. For a major part of the course, students will use state-of-the-art computer software to determine the protein structure themselves. An introduction to each session will be given and the students will work on the various tasks independently; supervision will be provided ad hoc. The course will be accompanied by the X-ray crystallography seminars within the department. |
Course Delivery Information
|
| Delivery period: 2010/11 Semester 1, Not available to visiting students (SS1)
|
WebCT enabled: Yes |
Quota: None |
| Location |
Activity |
Description |
Weeks |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
| King's Buildings | Lecture | | 1-11 | 13:10 - 14:50 | | | | |
| First Class |
First class information not currently available |
| Additional information |
1 hour(s) per week for 10 week(s). |
Summary of Intended Learning Outcomes
Overall: a working knowledge of the crystallographic software in current use for protein crystal structure determination (i.e. the CCP4 package).
Specifically: crystal preparation and X-ray data collection
space-group determination and data reduction
methods for phase determination
electron density map calculation and interpretation
model building and refinement
|
Assessment Information
1. Prepared seminar (20%)
2. Written examination at the end of the course (i.e. in December Wk 12 or 13) (80%) |
Special Arrangements
| Not entered |
Contacts
| Course organiser |
Prof Lindsay Sawyer
Tel: (0131 6)50 7062
Email: L.Sawyer@ed.ac.uk |
Course secretary |
Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk |
|
copyright 2010 The University of Edinburgh -
1 September 2010 6:24 am
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