Postgraduate Course: Molecular Modelling and Database Mining (PGBI11023)
Course Outline
| School |
School of Biological Sciences |
College |
College of Science and Engineering |
| Course type |
Standard |
Availability |
Available to all students |
| Credit level (Normal year taken) |
SCQF Level 11 (Postgraduate) |
Credits |
10 |
| Home subject area |
Postgraduate |
Other subject area |
None |
| Course website |
None |
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| Course description |
This module will expose the student to the computational methods involved in structure-based drug design. The student will work on a small project carry out the different steps with a high degree of independence. Supervision will be provided on an introductory basis as well as ad hoc. |
Course Delivery Information
|
| Delivery period: 2010/11 Semester 1, Available to all students (SV1)
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WebCT enabled: Yes |
Quota: None |
| Location |
Activity |
Description |
Weeks |
Monday |
Tuesday |
Wednesday |
Thursday |
Friday |
| No Classes have been defined for this Course |
| First Class |
First class information not currently available |
Summary of Intended Learning Outcomes
Overall: a working knowledge of the software and approaches in current use for protein modelling and structure-based drug design.
Specifically:
1. BLAST, AA alignment, PDB, PFAM,
Given a protein aa sequence, search for homologous proteins. Identify available crystal structures. Secondary structure prediction.
2. Homology modelling
Generate a homology model using suitable software (Modeller, etc).
3. Database mining with LIDAEUS
Search for suitable compounds to bind in the active site by means of virtual screening.
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Assessment Information
| Computer-based examination at the end of the course (December week 12 or 13) |
| Please see Visiting Student Prospectus website for Visiting Student Assessment information |
Special Arrangements
| Not entered |
Contacts
| Course organiser |
Dr Paul Taylor
Tel: (0131 6)50 7058
Email: p.taylor@ed.ac.uk |
Course secretary |
Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk |
|
copyright 2010 The University of Edinburgh -
1 September 2010 6:24 am
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