Postgraduate Course: Protein Structure Determination (PGBI11021)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Not available to visiting students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 10 |
| Home subject area | Postgraduate |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | This course will provide a hands-on approach in protein structure determination. Students will be given a data set of X-ray diffraction images and the structure of a protein will be determined by molecular replacement. For a major part of the course, students will use state-of-the-art computer software to determine the protein structure themselves. An introduction to each session will be given and the students will work on the various tasks independently; supervision will be provided ad hoc. The course will be accompanied by the X-ray crystallography seminars within the department. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | One year of University level Chemistry or Biochemistry. A knowledge of elementary Physics would be an advantage. |
| Additional Costs | None |
Course Delivery Information
|
| Delivery period: 2013/14 Semester 2, Not available to visiting students (SS1)
|
Learn enabled: Yes |
Quota: None |
|
Web Timetable |
Web Timetable |
| Class Delivery Information |
1 hour(s) per week for 10 week(s). |
| Course Start Date |
13/01/2014 |
| Breakdown of Learning and Teaching activities (Further Info) |
Total Hours:
100
(
Lecture Hours 30,
Summative Assessment Hours 9,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
59 )
|
| Additional Notes |
|
| Breakdown of Assessment Methods (Further Info) |
Written Exam
80 %,
Coursework
20 %,
Practical Exam
0 %
|
| Exam Information |
| Exam Diet |
Paper Name |
Hours & Minutes |
|
| Main Exam Diet S2 (April/May) | Protein Structure Determination | 2:00 | |
Summary of Intended Learning Outcomes
Overall: a working knowledge of the crystallographic software in current use for protein crystal structure determination (i.e. the CCP4 package).
Specifically: crystal preparation and X-ray data collection
space-group determination and data reduction
methods for phase determination
electron density map calculation and interpretation
model building and refinement
|
Assessment Information
1. Prepared seminar (20%)
2. Written examination at the end of the course (i.e. in May) (80%) |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | PSD |
Contacts
| Course organiser | Prof Lindsay Sawyer
Tel: (0131 6)50 7062
Email: L.Sawyer@ed.ac.uk |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk |
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