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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2013/2014
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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Course typeStandard AvailabilityNot available to visiting students
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) Credits10
Home subject areaPostgraduate Other subject areaNone
Course website None Taught in Gaelic?No
Course description**Online Distance Learning Course**

In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Additional Costs None
Course Delivery Information
Delivery period: 2013/14 Semester 2, Not available to visiting students (SS1) Learn enabled:  No Quota:  None
Web Timetable Web Timetable
Course Start Date 17/02/2014
Breakdown of Learning and Teaching activities (Further Info) Total Hours: 100 ( Online Activities 20, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 78 )
Additional Notes
Breakdown of Assessment Methods (Further Info) Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
No Exam Information
Summary of Intended Learning Outcomes
At the end of this course students should be able to:

Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
Take an unknown model and test its reliability using software that tests its probity;
Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
Appreciate the concept of phase bias in electron density maps;
Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
Assessment Information
50% = Group Assessment (including maximum 20% variation for Peer Assessment of contribution)

50% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
Special Arrangements
None
Additional Information
Academic description Not entered
Syllabus Not entered
Transferable skills Not entered
Reading list Not entered
Study Abroad Not entered
Study Pattern Not entered
KeywordsSDDT
Contacts
Course organiserProf Lindsay Sawyer
Tel: (0131 6)50 7062
Email: L.Sawyer@ed.ac.uk
Course secretaryMiss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk
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