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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2013/2014
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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: High Throughput Drug Discovery (PGBI11077)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Course typeStandard AvailabilityNot available to visiting students
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) Credits10
Home subject areaPostgraduate Other subject areaNone
Course website None Taught in Gaelic?No
Course description**Online Distance Learning Course**

The original focus of High throughput screening in drug discovery was on automating assay techniques so that large libraries of molecules could be screened against disease relevant assays. Over time, however, it has developed to include combinatorial synthesis techniques and the design of combinatorial screening libraries. The ultimate aim in this area is to reduce the synthesis and screening costs per compound allowing routine screening of large custom libraries against a wide array of assays.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Additional Costs None
Course Delivery Information
Not being delivered
Summary of Intended Learning Outcomes
At the end of this course students should be able to:
& Understand the basics of assay design for use in large scale multiwell robotic screening environments
& Be aware of the issues of reproducibility and false positive/negative signal generation in these types of assay platforms.
& Describe the principles of combinatorial chemistry as applied to the drug discovery process.
& Connect the use of computational chemistry techniques to the design of targeted libraries for drug discovery.
& Be aware of the current developments in solid phase combinatorial chemistry and the impact of single synthesis bead assay techniques.
Assessment Information
50 % group assessment (including maximum 20% variation for Peer Assessment of contribution)

50 % electronic portfolio comprising learning log and contribution to Skills Profile
Special Arrangements
None
Additional Information
Academic description Not entered
Syllabus Not entered
Transferable skills Not entered
Reading list Not entered
Study Abroad Not entered
Study Pattern Not entered
KeywordsHighTDD
Contacts
Course organiserDr Paul Taylor
Tel: (0131 6)50 7058
Email: p.taylor@ed.ac.uk
Course secretaryMiss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk
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