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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2013/2014
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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Modelling Metabolic Pathways (PGBI11080)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Course typeStandard AvailabilityNot available to visiting students
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) Credits10
Home subject areaPostgraduate Other subject areaNone
Course website None Taught in Gaelic?No
Course descriptionAll cells rely on a complex interacting network of numerous metabolic pathways. Each pathway in turn requires the concerted and well-regulated action of a team of enzymes. These pathways with their component enzymes frequently make attractive drug targets. Metabolic pathways in the parasitic protist Trypanosoma brucei (the causative agent of African sleeping sickness) will be used to illustrate how a combination of biochemical, genetic, control analysis and computer simulation approaches can be used to obtain useful working models of these pathways.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Additional Costs None
Course Delivery Information
Not being delivered
Summary of Intended Learning Outcomes
At the end of this course students should be able to:
& Appreciate the variability of metabolic status during different life stages of an organism.
& Determine control strengths of individual components of metabolic pathways under defined conditions.
& Model how changes in metabolite concentrations will affect flux through a pathway.
& Explain why particular enzyme components of a pathway may be better drug targets than others.
& Devise strategies to explore possible synergy effects when more than one enzyme is inhibited.
Assessment Information
50 % group assessment (including maximum 20% variation for Peer Assessment of contribution)

50 % electronic portfolio comprising learning log and contribution to Skills Profile
Special Arrangements
None
Additional Information
Academic description Not entered
Syllabus Not entered
Transferable skills Not entered
Reading list Not entered
Study Abroad Not entered
Study Pattern Not entered
KeywordsMMP
Contacts
Course organiserProf Peter Swain
Tel: (0131 6)50 5451
Email: peter.swain@ed.ac.uk
Course secretaryMiss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk
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