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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2013/2014
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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Genetics of Human Complex Traits (PGBI11083)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Course typeStandard AvailabilityNot available to visiting students
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) Credits10
Home subject areaPostgraduate Other subject areaNone
Course website None Taught in Gaelic?No
Course descriptionThis course focuses on genetic and genomic approaches appropriate for the study of human populations. The course will emphasise analyse of both genetic disorder, and complex traits within the normal ranges and in the context of disease. It will identify the practical aspects
associated with such analyses in human populations due to the structure and organisation of the human population and the importance of late-onset-disorders.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Students MUST have passed: Population and Quantitative Genetics (PGBI11001)
Co-requisites Students MUST also take: Quantitative Genetic Models (PGBI11085) AND Linkage and Association in Genome Analysis (PGBI11086)
Prohibited Combinations Other requirements None
Additional Costs None
Course Delivery Information
Delivery period: 2013/14 Semester 2, Not available to visiting students (SS1) Learn enabled:  Yes Quota:  None
Web Timetable Web Timetable
Course Start Date 13/01/2014
Breakdown of Learning and Teaching activities (Further Info) Total Hours: 100 ( Lecture Hours 24, Supervised Practical/Workshop/Studio Hours 6, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 68 )
Additional Notes
Breakdown of Assessment Methods (Further Info) Written Exam 50 %, Coursework 50 %, Practical Exam 0 %
No Exam Information
Summary of Intended Learning Outcomes
On successfully completing the course, students will be able to demonstrate an understanding of the practical application of genomics and genome analysis to the analysis of human populations and genetic disorders. They will be conversant with inherent difficulties and opportunities facing such analyses, and the multiple approaches that have been implemented. They will be conversant with the integration of multiple genome-wide approaches and the value of genetic models.
Assessment Information
One class test (50%) plus one assignment (50%)
Special Arrangements
None
Additional Information
Academic description Not entered
Syllabus Session Topic
1 Introduction to complex traits and how to identify a disorder with a genetic component.
2 Human population diversity, population stratification & admixture.
3 Genetic testing & screening, Bayesian risk prediction.
4 Linkage analysis I: Quantitative traits. Extended families, nuclear families,phenotype definition, confounders.
5 Linkage analysis II: Genetic disorders. Diagnosis, liability classes, penetrance,heterogeneity. Strategies for late-onset diseases.
6 Association studies design, confounders, familial versus sporadic,
endophenotypes.
7 Genome-wide association studies of quantitative traits in healthy populations and in the context of disease, regional/genome-wide prediction.
8 Genome-wide association studies of genetic disorders (case:control) identifying genes for complex genetic disorders, computational and
bioinformatic tools.
9 Animal models: ENU mutagenesis, knockouts, conditional knockouts.
10 Transcriptomics and proteomics high throughput methodologies, gene expression, protein interactions, pathway analysis.
Transferable skills Not entered
Reading list Not entered
Study Abroad Not entered
Study Pattern The course consists of 10 x 3hr sessions, comprised of lectures, tutorials and computer-based practicals.
KeywordsGHCT
Contacts
Course organiserProf Andrew Leigh-Brown
Tel: (0131 6)50 5523
Email: A.Leigh-Brown@ed.ac.uk
Course secretaryMrs Jennifer Morris
Tel: (0131 6)50 5513
Email: jennie.morris@ed.ac.uk
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