Postgraduate Course: High Throughput Drug Discovery (PGBI11077)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Not available to visiting students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 10 |
| Home subject area | Postgraduate |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | **Online Distance Learning Course**
The original focus of High throughput screening in drug discovery was on automating assay techniques so that large libraries of molecules could be screened against disease relevant assays. Over time, however, it has developed to include combinatorial synthesis techniques and the design of combinatorial screening libraries. The ultimate aim in this area is to reduce the synthesis and screening costs per compound allowing routine screening of large custom libraries against a wide array of assays. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | None |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
At the end of this course students should be able to:
&· Understand the basics of assay design for use in large scale multiwell robotic screening environments
&· Be aware of the issues of reproducibility and false positive/negative signal generation in these types of assay platforms.
&· Describe the principles of combinatorial chemistry as applied to the drug discovery process.
&· Connect the use of computational chemistry techniques to the design of targeted libraries for drug discovery.
&· Be aware of the current developments in solid phase combinatorial chemistry and the impact of single synthesis bead assay techniques.
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Assessment Information
50 % group assessment (including maximum 20% variation for Peer Assessment of contribution)
50 % electronic portfolio comprising learning log and contribution to Skills Profile
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Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Not entered |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | HighTDD |
Contacts
| Course organiser | Dr Paul Taylor
Tel: (0131 6)50 7058
Email: p.taylor@ed.ac.uk |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk |
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