Postgraduate Course: Mechanics and Biomechanics of Cells, Tissues and Organs (MSc) (PGEE11111)
Course Outline
| School | School of Engineering |
College | College of Science and Engineering |
| Course type | Standard |
Availability | Available to all students |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Credits | 20 |
| Home subject area | Postgrad (School of Engineering) |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | The aim of this is to provide an introduction to the mechanics and biomechanics of health and disease with an emphasis on two areas; the musculoskeletal system and the cardiovascular system. In addition relevant principles will be applied to interventional methods including consideration of biomaterials and tissue engineering. For the cardiovascular system this will include wall shear stress (its role as a control parameter for the arterial system, and its role in disease development), and tissue stress (its role in plaque and aneurysm rupture). For the musculoskeletal system consideration will be given to the biomechanical behaviour of the skeleton, the muscles and joint surfaces. The mechanisms whereby forces are transduced into function (mechanotransduction) will be considered. The course will be lecture based.
This course includes elements of the course 'Engineering in Medicine 5'. |
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | Prior attendance at basic courses in physiology, fluid mechanics, soft-tissue mechanics and biomedical imaging is recommended. |
| Additional Costs | None |
Information for Visiting Students
| Pre-requisites | Prior attendance at basic courses in physiology, fluid mechanics, soft-tissue mechanics and biomedical imaging is recommended. |
| Displayed in Visiting Students Prospectus? | No |
Course Delivery Information
|
| Delivery period: 2013/14 Semester 2, Available to all students (SV1)
|
Learn enabled: Yes |
Quota: None |
Web Timetable |
Web Timetable |
| Course Start Date |
13/01/2014 |
| Breakdown of Learning and Teaching activities (Further Info) |
Total Hours:
200
(
Lecture Hours 34,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
162 )
|
| Additional Notes |
|
| Breakdown of Assessment Methods (Further Info) |
Written Exam
60 %,
Coursework
40 %,
Practical Exam
0 %
|
| Exam Information |
| Exam Diet |
Paper Name |
Hours:Minutes |
|
|
| Main Exam Diet S2 (April/May) | Paper 1 | 1:30 | | | | Main Exam Diet S2 (April/May) | Paper 2 | 1:00 | | |
Summary of Intended Learning Outcomes
- Understanding of cardiovascular and musculoskeletal disease.
- Understanding of the mechanics and biomechanics of cardiovascular and musculoskeletal systems.
- Understanding of mechanotransduction in the cardiovascular and musculoskeletal systems.
- Understanding of the mechanics and biomechanics of cardiovascular disease and musculoskeletal disease.
- Understanding of the application of imaging and modelling in-vivo to obtain information on forces.
- Understanding of how biomechanical considerations influence intervention in patients.
- Understanding of tissue engineering and biomaterials. |
Assessment Information
Assignments will include those from the 'Engineering in Medicine 5' course with additional assignments for the cardiovascular lectures.
Written assignment (40%) Examinations (60%)
Written assignments:
2 essays of 3,000 words; one on cardiovascular, one covering all other topics.
Examinations:
Part A. 1.5 hour paper; short answer (1 hour) + long answers (30 mins). Same exam as for 'Engineering in Medicine 5' course.
Part B. 1 hour paper; short answer (30 mins) + long answers (30 mins). |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Note: lectures are the same as 'Engineering in Medicine 5' with an additional 12 lectures.
1. Biomechanics of the Musculoskeletal System 1
2. Biomechanics of the Musculoskeletal System 2
3. Soft Tissue Mechanics 1: Viscoelasticity
4. Soft Tissue Mechanics 2: Non-linear Viscoelasticity
5. Bone Architecture & Hard Tissue Mechanics
6. Bone Fractures, Healing and Fracture Fixation
7. The Synovial Joint
8. Hip Replacement
9. TJR Failure
10. Guest lecture: Total Knee Replacement: A Surgeon¿s Perspective
11. Knee Replacement
12. Biomaterials and Biocompatibility 1
13. Biomaterials and Biocompatibility 2
14. Biomaterials and Biocompatibility 3
15. Basic Biomechanics
16. The Spine and Its Interventions
17. The Hand and Interventions
18. Tissue Engineering 1
19. Tissue Engineering 2
20. Rehabilitation Engineering 1
21. Rehabilitation Engineering 2
22. The Legal Framework for Medical Devices
23. Overview of cardiovascular disease
24. Mechanics of the normal circulation
25. Mechanics of atherosclerosis and AAA
26. Blood, blood flow, viscometry, margination etc
27. Leukocyte dynamics
28. Thombus formation.
29. Modelling thrombus formation experimentally.
30. Simulation and image guided modelling in arteries in-vivo.
31. Endothelial biology.
32. Endothelial mechanics and mechanotransduction.
33. Arterial stiffening, causes, measurement and endothelial function.
34. Cardiovascular operations ¿ biomechanics and the surgeons perspective |
| Transferable skills |
Not entered |
| Reading list |
Main text:
Introductory Biomechanics: From Cells to Organisms. Ethier and Simmons, CUP, 2007.
Other cardiovascular texts:
Biofluid mechanics - the human circulation. Chandran, Yoganathan, Rittgers. CRC Taylor & Francis, second edition. 2012
Biofluid mechanics in cardiovascular systems. Waite. McGraw Hill, 2006.
The mechanics of the circulation. Caro et al, CUP, 1978 (reprinted 2011)
Other musculoskeletal texts:
Musculoskeletal biomechanics. Brinckmann, Thieme, 2000
Basic biomechanics of the musculoskeletal system, third edition. Nordin. Lippincott Williams and Wilkins, 2001.
Tissue engineering and biomaterials:
Biomaterials Science, Second Edition: An Introduction to Materials in Medicine, Ed. Buddy Ratner et al., 2nd Edition
Note: Ebook available free at ¿Engineering Village¿ linked from Uni Library search
General Bioengineering:
The Biomedical Engineering Handbook, 3rd Edition, by Joseph D. Bronzino (Editor) |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | Cardiovascular, musculoskeletal, tissue engineering, mechanotransduction, biomaterials, biomechanics |
Contacts
| Course organiser | Dr Peter Hoskins
Tel: 0131 242 6305
Email: Peter.Hoskins@ed.ac.uk |
Course secretary | Mrs Sharon Mulvey
Tel: (0131 6)51 7076
Email: Sharon.Mulvey@ed.ac.uk |
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