Undergraduate Course: Cilia: cellular antennae in development, physiology and disease (PYBM10032)
Course Outline
| School | School of Biomedical Sciences |
College | College of Medicine and Veterinary Medicine |
| Course type | Standard |
Availability | Not available to visiting students |
| Credit level (Normal year taken) | SCQF Level 10 (Year 4 Undergraduate) |
Credits | 10 |
| Home subject area | Physiology (Biomedical Sciences) |
Other subject area | None |
| Course website |
None |
Taught in Gaelic? | No |
| Course description | Cilia are near-ubiquitous cellular organelles that perform a variety of sensory and motility functions. They are essential to the physiology of many organ systems and also during embryonic development. In the past few years there has been an explosion of interest in cilia as it has become apparent that defective ciliary structure or function underlies a wide range of medical conditions.
This course is intended to provide students with a critical understanding of cilia biology and its relevance to development, physiology and disease. It will include:
-Basic cilia structure, function and distribution.
-Current research on ciliogenesis, including how ciliary biology is being advanced by use of model organisms and cutting edge technologies.
-Sensory and motile roles for cilia in a variety of organ systems, including lung, kidney, sense organs, reproductive system.
-The many ways is which ciliary defects can cause disease (e.g. polycystic kidney disease, ciliopathies, infertility).
Weekly sessions will consist of a 1 hour lecture followed by discussion of research papers. The lecture will introduce the papers to be discussed for the following week. In this way students will be expected to supplement the lecture with library work and then be prepared to discuss the papers in the next session. Discussions will either be as a group or based around student presentations. In some sessions, guest lecturers will talk about their research, followed by a group discussion.
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
| Additional Costs | no |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
¿ Detailed knowledge of the important contribution of cilia to the function of multiple organ systems and to embryonic development
¿ Understand how ciliary structure relates to function
¿ Give detailed examples of how defects in ciliary structure, function, and biosynthesis lead to disease.
¿ Critically compare the organismal and cellular models used in cilia research with an ability to discuss strengths and weaknesses of them
¿ Summarise the roles of different methodologies used in ciliary research, particularly with examples transcriptomics and proteomics.
¿ Critically evaluate the literature around this topic
¿ Review knowledge generated throughout the course and present findings in a cohesive manner in written or oral presentation
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Assessment Information
| Final exam (100%) |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
YBA |
| Transferable skills |
Not entered |
| Reading list |
Not entered |
| Study Abroad |
Not entered |
| Study Pattern |
Not entered |
| Keywords | Cell biology, animal models, sensory reception, organ systems |
Contacts
| Course organiser | Dr Mike Ludwig
Tel: (0131 6)50 3275
Email: Mike.Ludwig@ed.ac.uk |
Course secretary | Mrs Patricia Law
Tel: (0131 6)50 3161
Email: Anne.Law@ed.ac.uk |
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