Undergraduate Course: Integrative Physiology (BIME10018)
|School||School of Biomedical Sciences
||College||College of Medicine and Veterinary Medicine
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||What has dietary salt got to do with hypertension? How can an ion channel coded by a single gene have distinct properties and physiological roles? Why is controlling cell volume so important for normal physiology? How may oxygen and thus energy (ATP) supply be regulated at the cellular and whole body level?
Questions such as these will be addressed in a course that examines how fundamental cellular and transport processes are regulated and co-ordinated to control whole organism physiology. Key concepts will be illustrated with examples drawn from the following topics:
1: Ion transporter control and the regulation of blood pressure
2: Regulation of potassium channels: molecules to maladies
3: Calcium signaling and metabolic control: from cell to system
4: Cell volume control: a key regulator of cell life and death
The roles of pumps, ion channels and cotransporters will be examined, and we will consider how the diversity and activity of these regulatory elements are affected by posttranscriptional and posttranslational modifications.
The elective is designed to convey the stimulating atmosphere of cutting edge science with an emphasis on experimental approaches and evidence - from single molecules, through their interactions and functional roles in intact organisms, to the insight this provides into diseases and their treatment. Participants will develop skills in critical evaluation and précis of scientific studies and experimental design, and will make scientific presentations to a critical audience.
During the module you will:
become acquainted with key topics through a series of seminars, readings and practical problems.
become familiar with the major experimental methods through a series of seminars and demonstrations.
critically review, summarise and present original research.
Entry Requirements (not applicable to Visiting Students)
|| Students MUST have passed:
Biomedical Sciences 3 (BIME09008) AND
Physiology 3 (BIME09004) OR
Pharmacology 3 (BIME09003)
||Other requirements|| Students who are either enrolled on the BSc (Hons) Medical Sciences, or who spent their third year abroad, or who are taking an intercalated year, are exempt from the requirement to have taken and passed Biomedical Sciences 3
Course Delivery Information
|Academic year 2014/15, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
||Please contact the School directly for a breakdown of Learning and Teaching Activities
|Assessment (Further Info)
|Additional Information (Assessment)
||In course assessment: Scientific synopsis (20%)
Degree examination: (80%)
|No Exam Information
| Understand the experimental approaches and tools available to study integrative physiology: from single molecules to whole organisms
Appreciate how historical and evolutionary perspectives inform development of physiological knowledge
Define the cell as the functional unit of Integrative Physiology
Discuss how membranes and regulation of ion transport processes are key gateways to controlling physiological homeostasis
Understand the mechanisms that create physiological diversity.
|Graduate Attributes and Skills
|Keywords||Physiology, Pharmacology, ion channel, transporter, integration, membrane biology, signalling, post-
|Course organiser||Prof Michael Shipston
Tel: (0131 6)50 3253
|Course secretary||Mr Neale Summers
Tel: (0131 6)51 3094
© Copyright 2014 The University of Edinburgh - 12 January 2015 3:31 am