Undergraduate Course: Th2 in Immunity, Allergy and Health (IMMU10013)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||The dichotomy of T cell responses into Th1 and Th2 remains a major paradigm in immunology, despite the appearance of multiple other T cell subsets. This unit will focus on the development and functions of the Th2 arm, which is uniquely responsible for a suite of essential immune defences (eg against helminth parasites), but also associated with specific pathologies (eg allergy) as well as body maintenance functions (wound healing and metabolism). By studying Th2, we can readily illustrate and understand the regulation and balance within the immune system that dictates when different modes of immunity are selected or repressed, thereby leading to better therapies for infection or immune dysfunction.
A further fascinating aspect of this topic is the complementarity between the innate and adaptive immune systems, particularly with the recent definition of innate lymphoid cells which mirror the functions of Th2 cells. Moreover, there is a important set of "Type 2" innate effector cells, including eosinophils, basophils and alternatively activated macrophages, which are involved in both the induction of Th2 response but also in executing effector functions downstream of Th2 signals. These cells are also intimately linked with wound healing and the response to injury, as well as maintaining optimal metabolic status, because Th1/Th2 imbalance is associated with various forms of physiological malfunctions such as type II diabetes and cardiovascular diseases.
The module will include both lectures and analysis of the primary literature. The course will start with lectures on the basic differentiaton and function of Th2 cells, as well as an overview of the innate Type 2 populations, together with an evolutionary perspective of the Th2 arm of immunity. Following sessions will be a combination of lectures focussing on specific themes and discussion of the primary literature. Topics covered will include immunity to helminths, the development of allergy, modes of regulation of the Th2 response, and the role of the Type 2 response in wound healing and metabolism. Review of the primary literature will be in the form of presentations and question-and-answer sessions. Students will be expected to read the papers in advance and actively engage in an analysis of the papers┐ findings.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Academic year 2014/15, Not available to visiting students (SS1)
|Course Start Date
|Learning and Teaching activities (Further Info)
Lecture Hours 25,
Summative Assessment Hours 2,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||There will be a final 2 hour exam in December (Week 12-13) contributing 100% to the final mark.
||Hours & Minutes
|Main Exam Diet S1 (December)||Th2 in Immunity, Allergy and Health||2:00|
| Basic understanding of the current field of Th2 immunology.
Advanced skills in reading and understanding the primary literature.
Development of scientific problem solving skills
|Graduate Attributes and Skills
|Course organiser||Prof Rick Maizels
Tel: (0131 6)50 5511
|Course secretary||Miss Claire Fox
Tel: (0131 6)50 5454
© Copyright 2014 The University of Edinburgh - 12 January 2015 4:10 am