Undergraduate Course: Cellular Calcium Signalling (PHBM10031)
Course Outline
| School | School of Biomedical Sciences |
College | College of Medicine and Veterinary Medicine |
| Credit level (Normal year taken) | SCQF Level 10 (Year 4 Undergraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 10 |
ECTS Credits | 5 |
| Summary | This course will consider our current understanding of the mechanisms of intracellular calcium signalling. An historical perspective of this research area will be given, and lead up to a consideration of our current knowledge of the cellular and molecular processes involved. Conventional and state-of-the-art methodology will be incorporated into these lectures. Thereafter, the diversity of cellular processes that are regulated by calcium will be discussed in light of recent advances in our understanding of calcium signalling in cellular micro- / nano-domains. |
| Course description |
1. Mechanisms of calcium signalling ¿ A.M. Evans
2. Cellular nanodomains ¿ A.M. Evans
3. Calcium-sensitive ion channels in the plasma membrane ¿ M.J. Shipston
4. Calcium-dependent regulation of exocytosis and vesicle trafficking ¿ M. Cousin
5. Calcium-dependent regulation of gene expression ¿ G. Hardingham
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
Students MUST have passed:
Pharmacology 3 (BIME09003)
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
| Not being delivered |
Learning Outcomes
Demonstrate knowledge and understanding of:
The mechanisms of intracellular calcium signalling;
The roles of the recognised calcium mobilising messengers (cADPR, NAADP, IP3) and their respective receptor subtypes (IP3 receptors, ryanodine receptors, two pore domain channels);
What is known about the processes that underpin calcium mobilisation from the sarco / endoplasmic reticulum and acidic endolysosome calcium stores;
What is a cellular nanodomain and how may nanodomains allow for differential regulation by calcium of different and on occasion opposing cellular processes (e.g. smooth muscle contraction and relaxation, exocytosis, gene expression, apoptosis);
Demonstrate an ability to:
Develop a critical understanding of different models, concepts and experimental approaches in the field of calcium signalling;
Make constructive use of the information provided to design / develop future experiments;
Take an informed part in debate about contentious issues that exist within the field of calcium signalling;
Identify and develop potential research questions for future study.
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Reading List
Zhu MX, Ma J, Parrington J, Calcraft PJ, Galione A & Evans AM. (2010b). Calcium signaling via two-pore channels: local or global, that is the question. Am J Physiol Cell Physiol 298, C430-441.
Berridge MJ. Inositol trisphosphate and calcium signalling mechanisms. Biochim Biophys Acta 1793: 933¿940, 2009.
Lee HC. Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41: 317¿345, 2001.
Gyorke S, Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res 77: 245¿255, 2008.
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Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | CCS |
Contacts
| Course organiser | Dr David Wyllie
Tel: (0131 6)50 4564
Email: David.J.A.Wyllie@ed.ac.uk |
Course secretary | Mr Neale Summers
Tel: (0131 6)51 3094
Email: n.summers@ed.ac.uk |
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