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DRPS : Course Catalogue : Deanery of Biomedical Sciences : Biomedical Sciences

Undergraduate Course: Inflammation and Tissue Repair (BIME10036)

Course Outline
SchoolDeanery of Biomedical Sciences CollegeCollege of Medicine and Veterinary Medicine
Credit level (Normal year taken)SCQF Level 10 (Year 4 Undergraduate) AvailabilityNot available to visiting students
SCQF Credits20 ECTS Credits10
SummaryThis course will provide training in the cell biology of inflammation and the understanding of inflammatory disease, developing an integrated view of inflammatory responses in terms of cell biology, physiology and pathology, with teaching sessions moderated by both biomedical and clinical scientists.

This course will provide an introduction to inflammation and inflammatory disease, giving an integrated immunological viewpoint of the development and resolution of inflammatory responses and disease. The major themes will be (1) Inflammatory Cells, (2) Innate and Adaptive Immune Mechanisms, (3) Inflammatory Mediators and therapeutic intervention (4) Resolution of Inflammation and (5) Pathogenesis of Inflammatory Disease. Knowledge of the mechanisms underlying control of inflammation at a molecular and cellular level will provide a background for discussions of the pathophysiological consequences of inflammatory diseases in different organs, particularly in the skin, lung and gastrointestinal tract, and the potential approaches to therapy.
Course description The course aims to complement those modules dealing with initiation of acquired immunity, outlining the general characteristics of an inflammatory response (eg. initiation, progression and ultimate resolution of inflammation). Specifically, the integration of molecular signals involved in generation of inflammatory response, including the acute phase response, will be detailed. The characteristics of the principal cell types involved in inflammation (mast cells, neutrophil and eosinophil granulocytes and mononuclear phagocytes) will be described, along with the role that inflammatory mediators and cytokines play in the acute phase response, inflammatory cell recruitment and ultimately the resolution of inflammation. At a molecular level, adhesion molecules, innate immune receptors, and pathogen clearance mechanisms will be outlined. The mechanisms involved in disease pathogenesis will be discussed, together with potential anti-inflammatory strategies. The course will contain seminar-based teaching sessions, student-led presentations and a group discussion session that will introduce and develop important concepts. Key transferable skills will also be developed, including oral presentation and effective writing.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites It is RECOMMENDED that students have passed Clinical Immunology & Haematology 3A (MSBM09005) OR Immunology 3 (BILG09007)
Prohibited Combinations Other requirements None
Course Delivery Information
Academic year 2016/17, Not available to visiting students (SS1) Quota:  25
Course Start Semester 1
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 200 ( Lecture Hours 40, Summative Assessment Hours 3, Revision Session Hours 2, Programme Level Learning and Teaching Hours 4, Directed Learning and Independent Learning Hours 151 )
Assessment (Further Info) Written Exam 70 %, Coursework 30 %, Practical Exam 0 %
Additional Information (Assessment) 30% ICA, 70% Exam
Feedback Feedback will be available throughout the course in many forms:
- Feedback from Course Organiser and other key teaching staff
- Mid-course feedback session, as well as several sessions later in the course to go over exam questions and techniques as well as specific student questions about topics has been
timetabled for students
- Feedback from the exam will be made available. Please contact the Course Administrator for more information about how and when this will be done
Exam Information
Exam Diet Paper Name Hours & Minutes
Main Exam Diet S1 (December)Inflamation and Tissue Repair (BIME10036)2:00
Learning Outcomes
On completion of this course, the student will be able to:
  1. Basic understanding of the current concepts in inflammatory processes
  2. Attainment of advanced skills in reading and understanding the primary literature
  3. Development of scientific problem solving skills
  4. Development of oral presentation skills
Reading List
1: Davies LC, Jenkins SJ, Allen JE, Taylor PR. Tissue-resident macrophages. Nat Immunol. 2013 Oct;14(10):986-95.

2: Poon IK, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 2014 Mar;14(3):166-80.

3: Novak ML, Thorp EB. Shedding light on impaired efferocytosis and nonresolving inflammation. Circ Res. 2013 Jun 21;113(1):9-12.

4: Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015 May;27(3):200-15.

5: Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013 Mar;13(3):159-75.

6: Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol. 2014 Mar;14(3):181-94.
Additional Information
Graduate Attributes and Skills Not entered
Course organiserDr Ian Dransfield
Tel: (0131 6)50 6948
Course secretaryMs Maria Schmidke
Tel: (0131 6)50 3161
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