Postgraduate Course: Protein Structure Determination (PGBI11021)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||This course will deal with aspects of protein structure determination using multiple techniques including protein crystallography, nuclear magnetic resonance and electron microscopy. In addition lectures showing how multiple techniques can be combined and on developing approaches to structural elucidation will be given.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| One year of University level Chemistry or Biochemistry. A knowledge of elementary Physics would be an advantage.
|Additional Costs|| None
Course Delivery Information
|Academic year 2016/17, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 30,
Formative Assessment Hours 2,
Summative Assessment Hours 9,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||1. Class Test (40%)
2. Essay (40%)
3. 10 minute presentation (20%)
|No Exam Information
On completion of this course, the student will be able to:
- Describe the major techniques used for protein structure determination, and in more detail the use of X-Ray diffraction and Nuclear Magnetic resonance in macromolecular structural determination
- Understand methods of crystal preparation and X-ray data collection, X-ray data reduction, methods for phase determination, electron density map calculation and interpretation.
- Summarise methods for peak assignment and distance constraint determination in NMR.
- Give an overview of sample preparation and data collection in Electron Microscopy.
|Graduate Attributes and Skills
|Additional Class Delivery Information
||2 hour(s) per week for 10 week(s).
|Course organiser||Dr Paul Taylor
Tel: (0131 6)50 7058
|Course secretary||Ms Andrea Nichol
Tel: (0131 6)50 8643
© Copyright 2016 The University of Edinburgh - 3 February 2017 4:51 am