Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)
Course Outline
School | School of Biological Sciences |
College | College of Science and Engineering |
Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
SCQF Credits | 10 |
ECTS Credits | 5 |
Summary | **Online Distance Learning Course**
In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
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Course description |
Not entered
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Entry Requirements (not applicable to Visiting Students)
Pre-requisites |
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Co-requisites | |
Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
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Academic year 2016/17, Not available to visiting students (SS1)
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Quota: None |
Course Start |
Semester 2 |
Timetable |
Timetable |
Learning and Teaching activities (Further Info) |
Total Hours:
100
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Online Activities 20,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
78 )
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Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
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Additional Information (Assessment) |
40% = Report
20% = Recorded Talk
40% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
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Feedback |
Not entered |
No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
- Take an unknown model and test its reliability using software that tests its probity;
- Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
- Appreciate the concept of phase bias in electron density maps;
- Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
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Additional Information
Graduate Attributes and Skills |
Not entered |
Keywords | SDDT |
Contacts
Course organiser | Dr Paul Mclaughlin
Tel: (0131 6)50 7060
Email: paul.mclaughlin@ed.ac.uk |
Course secretary | Mrs Claire Black
Tel: (0131 6)50 8637
Email: Claire.Black@ed.ac.uk |
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© Copyright 2016 The University of Edinburgh - 3 February 2017 4:51 am
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