Postgraduate Course: In Silico Drug Discovery (PGBI11079)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||**Online Distance Learning Course**
A major contributor of new leads to the drug discovery process is the large scale, normally database driven, modelling of ligand/macromolecular interactions or searches based on properties derived from pre-existing chemical entities. In this course these database mining techniques, along with allied chemical fragment based approaches, will be explored.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Academic year 2016/17, Not available to visiting students (SS1)
|Course Start Date
|Learning and Teaching activities (Further Info)
Online Activities 20,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||50 % group assessment (including maximum 20% variation for Peer Assessment of contribution)
50 % electronic portfolio comprising learning log and contribution to Skills Profile
|No Exam Information
On completion of this course, the student will be able to:
- At the end of this course students should be able to: Describe the major aspects of a virtual screening application, including the methods for initial site point generation, and the various approaches to pose fitting.
- Distinguish between force field/enthalpy based and knowledge based pose scoring methods.
- Understand the properties that increase the value of compound databases.
- Have a clear understanding of the values and problems associated with multiconformer vs single conformer chemical databases.
- Describe the major classes of similarity searching algorithms, and understand the types of problem that such programs can be applied to.
|Graduate Attributes and Skills
|Course organiser||Dr Douglas Houston
Tel: (0131 6)50 7358
|Course secretary||Mrs Claire Black
Tel: (0131 6)50 8637
© Copyright 2016 The University of Edinburgh - 3 February 2017 4:51 am