Postgraduate Course: Modelling Metabolic Pathways (PGBI11080)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 10 |
ECTS Credits | 5 |
| Summary | **Online Distance Learning Course**
All cells rely on a complex interacting network of numerous metabolic pathways. Each pathway in turn requires the concerted and well-regulated action of a team of enzymes. These pathways with their component enzymes frequently make attractive drug targets. Metabolic pathways in the parasitic protist Trypanosoma brucei (the causative agent of African sleeping sickness) will be used to illustrate how a combination of biochemical, genetic, control analysis and computer simulation approaches can be used to obtain useful working models of these pathways. |
| Course description |
Not entered
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
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Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
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| Academic year 2016/17, Not available to visiting students (SS1)
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Quota: None |
| Course Start |
Semester 2 |
| Course Start Date |
16/01/2017 |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
100
(
Online Activities 20,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
78 )
|
| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
|
| Additional Information (Assessment) |
50 % group assessment (including maximum 20% variation for Peer Assessment of contribution)
50 % electronic portfolio comprising learning log and contribution to Skills Profile
|
| Feedback |
Not entered |
| No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- Appreciate the variability of metabolic status during different life stages of an organism.
- Determine control strengths of individual components of metabolic pathways under defined conditions.
- Model how changes in metabolite concentrations will affect flux through a pathway.
- Explain why particular enzyme components of a pathway may be better drug targets than others.
- Devise strategies to explore possible synergy effects when more than one enzyme is inhibited.
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Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | MMP |
Contacts
| Course organiser | Dr Linda Gilmore
Tel: (0131 6)50 7047
Email: linda.gilmore@ed.ac.uk |
Course secretary | Mrs Claire Black
Tel: (0131 6)50 8637
Email: Claire.Black@ed.ac.uk |
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