Postgraduate Course: Drug Discovery (MSc Level) (PGBI11088)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||This course provides a broad overview of the drug discovery and development process, and in particular structure based drug design. Pharmaceutical drugs have traditionally developed from herbal remedies or from the random screening for beneficial effects of natural or synthetic chemicals. We now have a detailed understanding of many diseases at a molecular level.
The aim of this course is to explain how we can use the structure and function of proteins involved in a disease to discover new potential drug molecules. The course provides a background on how proteins are selected as potential disease targets and introduces the various biochemical, computational and biophysical techniques used in ligand discovery.
The course also has a practical component and computational workshops will provide hands-on experience with modeling and docking programs to identify potential small molecule ligands as potential inhibitors against a number of protein drug targets.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Academic year 2016/17, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 20,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||Group presentation (20%)
Group presentation of and submission of PowerPoint handout of 2 pages (12 slides in total) summarising the project and evaluating the target.
Written Report (80%)
Each student will write an individual report on a potential protein drug target.
|No Exam Information
On completion of this course, the student will be able to:
- Increased understanding of biological and biochemical systems.
- An overview of the methods used in structure-based drug design
- An appreciation of the role molecular structure and biochemical mechanisms play in the design of new drug modules
- Improved presentation skills
- Used molecular modelling software to visualise drug-target complexes
|Graduate Attributes and Skills
|Course organiser||Prof Malcolm Walkinshaw
Tel: (0131 6)50 3719
|Course secretary||Ms Andrea Nichol
Tel: (0131 6)50 8643
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