Undergraduate Course: Cardiovascular Pharmacology & Therapeutics (BIME10029)
|School||Deanery of Biomedical Sciences
||College||College of Medicine and Veterinary Medicine
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||Cardiovascular Pharmacology and Therapeutics will focus primarily on drugs used in the treatment of cardiovascular disease, both current drug classes and those in development. The aim is to understand how these drugs work and where new development is required. The course will introduce the basics of vascular biology, including a practical class on function of the vascular endothelium; as well as blood pressure control and the kidney, and mechanisms of angiogenesis. The course will then cover the major cardiovascular diseases, including the role of the endothelium in protection against vascular disease, antioxidants, and the the pathogenesis of atherosclerosis that can result in thrombosis, myocardial infarction (MI) and stroke. The course will also address the potential for new treatments to reduce injury associated with MI and to treat heart failure. Non-drug related therapeutics, such as stem cells and microRNAs will also be covered within these topics. The course will be taught as a combination of traditional lectures and linked tutorials based on analysis of original research papers. Students will be expected to contribute to tutorial sessions and will be required to make presentations to their classmates related to the themes of the course. The teachers on this course are drawn from a variety of backgrounds, mostly active researchers and clinicians from the Centre for Cardiovascular Science, Little France.
Entry Requirements (not applicable to Visiting Students)
|| Students MUST have passed:
Pharmacology 3 (BIME09003) AND
Biomedical Sciences 3 (BIME09008)
||Other requirements|| Students who are either enrolled on the BSc (Hons) Medical Sciences, or who spent their third year abroad, or who are taking an intercalated year, are exempt from the requirement to have taken and passed Biomedical Sciences 3.
Course Delivery Information
|Academic year 2017/18, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 18,
Seminar/Tutorial Hours 22,
Supervised Practical/Workshop/Studio Hours 2,
Formative Assessment Hours 2,
Summative Assessment Hours 4,
Revision Session Hours 2,
Other Study Hours 2,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
|Additional Information (Learning and Teaching)
learning skills session
|Assessment (Further Info)
|Additional Information (Assessment)
||ICA 20%, EXAM 80%
||Feedback will be available throughout the course in many forms:
: tutorials will allow direct feedback from the tutor.
:analysis of data generated during the practical will provide the opportunity for feedback on performance in the practical and on ability to interpret data.
¿ from course organiser and peers on your presentations to the class
¿ a focussed session at the end of the course to go over exam questions and techniques as well as specific student questions about topics.
¿ exam performance
||Hours & Minutes
|Main Exam Diet S1 (December)||Cardiovascular Pharmacology & Therapeutics||2:00|
| ¿ Understand the role of the endothelium in regulating arterial function.
¿ Understand the mechanism underlying angiogenic formation of new blood vessels.
¿ Develop a clear understanding of cardiovascular risk factors and the pathogenesis of cardiovascular disease (hypertension; atherosclerosis; heart failure).
¿ Understand the use of new therapeutic approaches to cardiovascular disease (eg. stem cell therapy).
¿ Interpret original experimental data and discuss the significance of the findings.
¿ Develop the ability to debate the scientific basis of cardiovascular physiology, pathophysiology and therapeutics.
¿ Demonstrate the ability give an oral to presentation summarising scientific results.
¿ Develop the ability to critically review current scientific literature relevant to cardiovascular physiology, pathophysiology and therapeutics.
¿ Develop the ability to frame clear hypotheses and aims and design appropriate experimental protocols for investigating the cardiovascular system.
|Martin, W, Villani, GM, Jothianandan, D & Furchgott, RF, (1984). Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by haemoglobin and by methylene blue in the rabbit aorta. The Journal of Pharmacology and Experimental Therapeutics: 232 (3), 708-716.|
Martin, W, Furchgott, RF, Villani, GM & Jothianandan, D (1986). Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor. The Journal of Pharmacology and Experimental Therapeutics: 237 (2), 529-538.
Bullock. GR, Taylor, SG, Weston, AH (1986) Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta. Br. J. Pharmacol., 89, 819-830.
|Graduate Attributes and Skills
||Require access to the Basement lab, 1, George Square, for practical classes.
The majority of teaching will take place in the Chancellors Building at Little France.
|Course organiser||Dr Gillian Gray
Tel: (0131 6)50 6817
|Course secretary||Mr Kevin Mcarthur
Tel: (0131 6)51 1824