Postgraduate Course: Protein Molecular Modelling Practical Skills (PGBI11111)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||During a typical molecular modelling project a protein structure might be modelled by homology modelling, its motions simulated by molecular dynamics and possible inhibitors discovered by virtual screening. This course will look in detail at these techniques, and the students will be given practical experience of them within a typical molecular modelling computational environment.
The course will take the structure of a series of discussed short presentations and/or practical sessions. Topics may carry across to later sessions if required. Students should read the papers given in learn before the requisite session.
Week 1 Presentation/discussion template structure selection for homology modelling/introduction to accompanying practical session
Week 2 Practical session on template selection
Week 3 Introduction to Essay assignment, example paper analysis
Week 4 Presentation/discussion homology model construction and validation
Week 5 Practical session concentrating on validation
Week 6 Presentation/discussion model preparation for molecular dynamics
Week 7 Practical session on preparing structure and starting dynamics run
Week 8 Presentation/discussion - dynamics trajectory analysis and validation
Week 9 Presentation/discussion - virtual screening methods.
Week 10 Practical session on virtual screening
Course Delivery Information
|Not being delivered|
On completion of this course, the student will be able to:
- demonstrate an understanding of the technologies that underpin the three featured techniques.
- demonstrate the ability to successfully complete and critically analyse the results from these techniques.
|Graduate Attributes and Skills
||Enhanced computing skills
|Course organiser||Dr Paul Taylor
Tel: (0131 6)50 7058
|Course secretary||Miss Sarah Harvey
Tel: (0131 6)51 7052