Postgraduate Course: Introduction to Molecular Pathology and Genomic Medicine (MCLM11056)
Course Outline
| School | Deanery of Molecular, Genetic and Population Health Sciences |
College | College of Medicine and Veterinary Medicine |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 10 |
ECTS Credits | 5 |
| Summary | Aims of the course:
1. To review the structure and function of the human genome as relevant to its role in human disease and, through worked examples enable the students to develop the practical skills to apply the knowledge gained to real life scenarios.
2. To support the development of an in-depth understanding of the principles of genome stability and carcinogenesis, in the context of Clinical Molecular Pathology
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| Course description |
This course aims to provide students with a detailed understanding of the principles of germline and somatic genome function, genome variation and the role of genetic variation in disease and the development of cancers, as the core knowledge required for subsequent courses in the PGCert in Molecular Pathology and Genomic Medicine.
The course will be structured into the following topics:
1. Introduction to the course
2. The structure and function of the human genome
3. Normal and abnormal variation in the human genome
4. Mechanisms of cancer development - somatic mutation and the hallmarks of cancer
5. Methods of genome analysis
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
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| Academic year 2017/18, Not available to visiting students (SS1)
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Quota: None |
| Course Start |
Semester 1 |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
100
(
Lecture Hours 2,
Seminar/Tutorial Hours 4,
Online Activities 8,
Feedback/Feedforward Hours 4,
Formative Assessment Hours 3,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
77 )
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| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
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| Additional Information (Assessment) |
Written Exam - 0%«br /»
Coursework - 100%«br /»
Practical Exam - 0%«br /»
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| Feedback |
Students will receive formative or summative feedback on all assessed pieces of work.
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| No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- Demonstrate a critical awareness of key principles and theories appertaining to genome structure and function, and mechanisms of variation.
- Critically apply this knowledge to the mechanisms of disease, cancer risk and cancer development.
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Reading List
The theory and practice of Molecular Pathology and Genomic Medicine is a very rapidly advancing field, and no single textbook is appropriate or sufficiently up to date. The course will draw on key established textbooks in the field, but will also use review papers and key research papers to ensure the most up to date learning for students. Example texts are given below.
Strachan T, Goodship J and Chinnery P. Genetics and Genomics in Medicine. Garland Science 2014. Print ISBN-10: 0815344805
Strachan T and Read A. Human Molecular Genetics 4th Ed. Garland Science 2010. Print ISBN-10: 0815341490
ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14;447(7146):799-816.
Zhang F, Gu W, Hurles ME, Lupski JR. Copy number variation in human health, disease, and evolution. Annu Rev Genomics Hum Genet. 2009;10:451-81
Hanahan D. and Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. |
Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | Molecular Pathology,Genetics,Genomic Medicine |
Contacts
| Course organiser | Dr Amy Hansen
Tel: (0131 6)51 8757
Email: Amy.Hansen@ed.ac.uk |
Course secretary | Mrs Alison Kyte
Tel: (0131 6)51 1041
Email: Alison.Kyte@igmm.ed.ac.uk |
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