Postgraduate Course: Somatic Mutations, Genomic Instability in Cancer and Infectious diseases (MCLM11057)
Course Outline
| School | Deanery of Molecular, Genetic and Population Health Sciences |
College | College of Medicine and Veterinary Medicine |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 20 |
ECTS Credits | 10 |
| Summary | Aims of the course:
1. To provide the background for the student to critically evaluate the different diagnostic and treatment approaches to site specific cancers.
2. To support the development of an in-depth understanding of the performance markers (sensitivity/specificity) of molecular tests in low copy number situations |
| Course description |
This course aims to provide students with a detailed understanding of the application of molecular testing to cancer diagnosis and therapeutic prediction including response to pharmacological therapy. The principles of low copy number analysis will also be explored.
The course will be structured into the following topics:
1. Assessment of diagnostic test performance
2. Stratification for therapy for site specific cancer
3. Monitoring of minimal residual disease
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Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
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| Academic year 2017/18, Not available to visiting students (SS1)
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Quota: None |
| Course Start |
Flexible |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
200
(
Lecture Hours 8,
Seminar/Tutorial Hours 4,
Online Activities 8,
Feedback/Feedforward Hours 6,
Formative Assessment Hours 4,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
166 )
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| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
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| Additional Information (Assessment) |
Written Exam - 0%«br /»
Coursework - 100%«br /»
Practical Exam - 0%«br /»
|
| Feedback |
Students will receive formative or summative feedback on all assessed pieces of work.
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| No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- Demonstrate a critical awareness of assessment of diagnostic test performance
- Critically apply the knowledge of molecular diagnostic techniques to the stratification and treatment of cancers
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Reading List
The theory and practice of Molecular Pathology and Genomic Medicine is a very rapidly advancing field, and no single textbook is appropriate or sufficiently up to date. The course will draw on key established textbooks in the field, but will also use review papers and key research papers to ensure the most up to date learning for students. Example texts are given below.
Strachan T, Goodship J and Chinnery P. Genetics and Genomics in Medicine. Garland Science 2014. Print ISBN-10: 0815344805
Strachan T and Read A. Human Molecular Genetics 4th Ed. Garland Science 2010. Print ISBN-10: 0815341490
ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14;447(7146):799-816.
Zhang F, Gu W, Hurles ME, Lupski JR. Copy number variation in human health, disease, and evolution. Annu Rev Genomics Hum Genet. 2009;10:451-81
Hanahan D. and Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. |
Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | Molecular Pathology,Genetics,Genomic Medicine |
Contacts
| Course organiser | Dr Amy Hansen
Tel: (0131 6)51 8757
Email: Amy.Hansen@ed.ac.uk |
Course secretary | Mrs Alison Kyte
Tel: (0131 6)51 1041
Email: Alison.Kyte@igmm.ed.ac.uk |
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