Undergraduate Course: Cancer Biology and Medicine (BIME10030)
|School||Deanery of Biomedical Sciences
||College||College of Medicine and Veterinary Medicine
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||This course will consider the genetic, molecular and cell biological processes involved in susceptibility to cancer and in the initiation and progression of the disease and show how this knowledge is being translated into improved cancer therapies. The Hallmarks and Emerging Hallmarks of Cancer will be discussed. The requirement for multiple genetic changes in the development of a metastatic cancer will be illustrated and the role of tumour suppressor genes and oncogenes will be described. The role of DNA repair in preventing genome instability will be discussed and some inherited DNA repair deficiency/ cancer susceptibility syndromes will be described. Alterations in cell cycle control, in proliferative cell signalling and cell death pathways in cancer cells will all be covered. Conventional surgical, radiotherapeutic and chemotherapeutic cancer treatments will be considered and new rational therapies that take into account both individual and cancer biodiversity will be discussed and illustrated for a number of major cancers: breast, ovarian, colorectal, lung and melanoma. Molecular profiling of cancers, identification of novel therapeutic targets, cancer drug development and trials of novel cancer therapies will all be considered. The course will consist of lectures, with some teacher-led discussions and non-assessed presentations by students working in groups. There will also be small group practical demonstrations of two important experimental approaches used in cancer research and a tutorial session. Before any student oral presentations there will be a feedback session on an assessed exercise where individual students will be asked to prepare and submit a 5-slide PowerPoint presentation on an early topic from the course.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Academic year 2018/19, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 42,
Feedback/Feedforward Hours 1,
Summative Assessment Hours 4,
Revision Session Hours 2,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||In course 40% (1 essay 30%; 1 Powerpoint presentation [submitted electronically not presented orally] 10%)
||There will be a feedback session after Assessment 1 (PowerPoint presentation) and Assessment 2 (Essay). Written feedback will also be provided on both Assessments. Verbal feedback will also be given after each Group Presentation.
||Hours & Minutes
|Main Exam Diet S1 (December)||1:30|
On completion of this course, the student will be able to:
- Understand how different genetic, molecular and cell biological processes are involved in susceptibility to cancer and in the initiation and progression of the disease.
- Understand the achievements and limitations of conventional cancer therapies, and how knowledge of cancer biology can be translated into improved cancer therapies.
- Understand how two key experimental approaches are used in cancer research.
- Demonstrate an ability to illustrate and present information regarding a specialised cancer topic in a short PowerPoint presentation.
- Demonstrate an ability to discuss the different pathways by which cancer cells invade and metastasise and the challenges that this presents for new therapeutic interventions.
|The Biology of Cancer by RA Weinberg is very good for much of the non-medical material covered. Second Edition, 2014, ISBN 978-0-8153-4220-5. First Edition, 2007, ISBN 0-8153-4076-1 is still good. There are copies of both in the Reserve Section of the Main Library. |
There is a separate reading list for each topic. The papers are all available as pdfs on Learn
|Graduate Attributes and Skills
|Course organiser||Prof David Melton
Tel: (0131 6)51 8706
|Course secretary||Ms Beth Muir
Tel: (0131 6)51 1513