Postgraduate Course: Concepts and Techniques in Bioanalytical Chemistry Level 11 (CHEM11045)
|School||School of Chemistry
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||This is a 20-credit Level 11 lecture course on the general subject of bioanalytical chemistry, available to students on selected PGT programmes. It is split across two themes. The first of these covers aspects of production, purification and characterisation of biomolecules and is intended to give students a firm grounding in the chemical nature of biomolecules. The second theme covers design of biosensors and aspects of analytical sampling and statistics and is intended to give students insight into the analysis, detection and quantification of biomolecules in real-world scenarios.
The course comprises of individual component lecture courses and associated tutorials or workshops. It is assembled from 15 lectures from the Biomacromolecules Level 11 course and 15 lectures from the Analytical Chemistry Level 11 course.
The course comprises individual lecture courses on: chemistry and structure of biomacromolecules; protein production, purification and engineering; statistics and data handling for analytical chemistry; principles of sampling and analysis; and biosensors.
The course content includes:
- the structures of complex biomacromolecules both in terms of their primary chemical composition and also their emergent secondary and tertiary structures.
- the biosynthesis as well as the laboratory-based manufacture and purification of biologically important polymers.
- how macromolecular 3D structure illuminates the understanding of mechanism and how (with examples) form follows function.
- through examples, the principles of molecular recognition and cooperation, molecular crowding and self-assembling multiprotein complexes.
- the principles of biosensor design from simple molecular recognition to transduction of binding events and be able to apply these in the context of detecting a variety of classes of target molecule.
- the relative merits of different strategies for sampling
- quality assurance procedures in support of an analytical measurement
- calibration curves and other statistical procedures to extract quantitative information from a measurement
- basic parametric and non-parametric significance tests on data
Course Delivery Information
|Academic year 2018/19, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 30,
Seminar/Tutorial Hours 9,
Summative Assessment Hours 3,
Revision Session Hours 6,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||This course will be examined in two 1.5 hour exams which run at the same time as Biomacromolecules Level 11 and Analytical Chemistry Level 11.
||Feedback is provided through the tutorials and workshops associated with the individual component lecture courses. Problem material will be made available for preparation in advance of the tutorial or workshop. Although these are not marked, material should always be attempted in advance as they are a good self-check on how well the material from the lectures has been understood, and the tutorials provide the opportunity to ask questions to resolve any difficulties with a particular topic. Opportunity for additional discussion and feedback for individual lecture courses is also arranged in the examination period.
||Hours & Minutes
|Main Exam Diet S2 (April/May)||Paper 1: Concepts and Techniques in Bioanalytical Chemistry (Analytical Chem Q)||1:30|
|Main Exam Diet S2 (April/May)||Paper 2: Concepts and Techniques in Bioanalytical Chemistry (Biomacromolecule Q)||1:30|
On completion of this course, the student will be able to:
- Show an understanding of the theory and application of a number of techniques in bioanalytical chemistry, as well of the general principles of sampling and analysis and of the statistical presentation and testing of data.
- Apply this knowledge to select and justify appropriate techniques for particular chemical or data analyses, including being able to integrate knowledge and skills across different areas of the course.
- Develop responses to problems and issues in aspects of bioanalytical chemistry and data analysis, demonstrating originality and creativity in how this knowledge is applied.
- Apply a set of numerical skills for solving quantitative bioanalytical chemistry and data analysis problems, including where required combination of these skills from different areas of the course.
- Demonstrate a professional approach to autonomy and time-management in relation to self-study and in the researching of additional material relevant to the course.
|Recommendations on further reading will be provided by the individual lecturers.|
|Graduate Attributes and Skills
Numerical data interpretation and analysis
Unseen problem solving skills
|Course organiser||Dr Mathew Heal
Tel: (0131 6)50 4764
|Course secretary||Miss Claire Dickson
Tel: (0131 6)51 7257