Postgraduate Course: Modelling Metabolic Pathways (PGBI11080)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
|Course type||Online Distance Learning
||Availability||Not available to visiting students
|Summary||**Online Learning Course**
All cells rely on a complex interacting network of numerous metabolic pathways. Each pathway in turn requires the concerted and well-regulated action of a team of enzymes. These pathways with their component enzymes frequently make attractive drug targets. Metabolic pathways in the parasitic protist Trypanosoma brucei (the causative agent of African sleeping sickness) will be used to illustrate how a combination of biochemical, genetic, control analysis and computer simulation approaches can be used to obtain useful working models of these pathways.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Not being delivered|
On completion of this course, the student will be able to:
- Appreciate the variability of metabolic status during different life stages of an organism.
- Determine control strengths of individual components of metabolic pathways under defined conditions.
- Model how changes in metabolite concentrations will affect flux through a pathway.
- Explain why particular enzyme components of a pathway may be better drug targets than others.
- Devise strategies to explore possible synergy effects when more than one enzyme is inhibited.
|Graduate Attributes and Skills
|Course organiser||Dr Paul Michels
|Course secretary||Mrs Claire Black
Tel: (0131 6)50 8637