Postgraduate Course: Linkage and Association in Genome Analysis (PGBI11086)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Available to all students |
| SCQF Credits | 20 |
ECTS Credits | 10 |
| Summary | This course builds on Population and Quantitative Genetics (in PGBI11001) and Statistics and Data Analysis (PGBI11003). It introduces the analytical approaches of linkage and association to dissect genetic variation and identify causative loci. |
| Course description |
The course has the following sessions involving lectures, tutorials and computer practicals:
1 Introduction to genomic data
2 Genetic linkage
3 + 4 QTL mapping using line crosses
5 + 6 Experimental design for QTL mapping
Significance levels in linkage and association
7 QTL mapping in complex pedigrees
8 Estimating heritability using markers
9 Linkage disequilibrium
10, 11 + 12 Association with quantitative traits
13 Case-control studies
14 + 15 Study design: imputation and meta-analyses
16 Post genome-wide association studies
17 Detecting rare variants
18 GWAS: Where are we now?
19 + 20 Discussion
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Information for Visiting Students
| Pre-requisites | Required: PGBI11001
Recommended: PGBI11003 and PGBI11085 |
| High Demand Course? |
Yes |
Course Delivery Information
|
| Academic year 2018/19, Available to all students (SV1)
|
Quota: 29 |
| Course Start |
Semester 2 |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
200
(
Lecture Hours 32,
Supervised Practical/Workshop/Studio Hours 24,
Programme Level Learning and Teaching Hours 4,
Directed Learning and Independent Learning Hours
140 )
|
| Assessment (Further Info) |
Written Exam
60 %,
Coursework
40 %,
Practical Exam
0 %
|
| Additional Information (Assessment) |
Two in-course assessments (data analysis reports) (each 20%), two centrally arranged exams (problem solving and essay) (each 30%). |
| Feedback |
Not entered |
| Exam Information |
| Exam Diet |
Paper Name |
Hours & Minutes |
|
| Main Exam Diet S2 (April/May) | Linkage & Association in Genome Analysis 1 (Open Book) | 1:30 | | | Main Exam Diet S2 (April/May) | Linkage & Association in Genome Analysis 2 (Closed book) | 1:30 | |
Learning Outcomes
On completion of this course, the student will be able to:
- understand the analytical approaches of linkage and association for the dissection of genetic variation of complex traits and the identification of causative loci
- identify the most appropriate analyses for particular problems being aware of the potential strengths and shortfalls of these techniques
- design a study to investigate the genetic variation of complex traits taking account of basic issues
- perform genome analyses of complex traits to dissect the genetic variation
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Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | LAGA |
Contacts
| Course organiser | Dr Sara Knott
Tel: (0131 6)50 5444
Email: s.knott@ed.ac.uk |
Course secretary | Mrs Jennifer Morris
Tel: (0131 6)50 5513
Email: jennie.morris@ed.ac.uk |
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