Undergraduate Course: Inflammation and Tissue Repair (BIME10036)
|School||Deanery of Biomedical Sciences
||College||College of Medicine and Veterinary Medicine
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||This course will provide training in the cell biology of inflammation and the understanding of inflammatory disease, developing an integrated view of inflammatory responses in terms of cell biology, physiology and pathology, with teaching sessions moderated by both biomedical and clinical scientists.
This course will provide an introduction to inflammation and inflammatory disease, giving an integrated immunological viewpoint of the development and resolution of inflammatory responses and disease. The major themes will be (1) Inflammatory Cells, (2) Innate and Adaptive Immune Mechanisms, (3) Inflammatory Mediators and therapeutic intervention (4) Resolution of Inflammation and (5) Pathogenesis of Inflammatory Disease. Knowledge of the mechanisms underlying control of inflammation at a molecular and cellular level will provide a background for discussions of the pathophysiological consequences of inflammatory diseases in different organs, particularly in the skin, lung and gastrointestinal tract, and the potential approaches to therapy.
The course aims to complement those modules dealing with initiation of acquired immunity, outlining the general characteristics of an inflammatory response (eg. initiation, progression and ultimate resolution of inflammation). Specifically, the integration of molecular signals involved in generation of inflammatory response, including the acute phase response, will be detailed. The characteristics of the principal cell types involved in inflammation (mast cells, neutrophil and eosinophil granulocytes and mononuclear phagocytes) will be described, along with the role that inflammatory mediators and cytokines play in the acute phase response, inflammatory cell recruitment and ultimately the resolution of inflammation. At a molecular level, adhesion molecules, innate immune receptors, and pathogen clearance mechanisms will be outlined. The mechanisms involved in disease pathogenesis will be discussed, together with potential anti-inflammatory strategies. The course will contain seminar-based teaching sessions, student-led presentations and a group discussion session that will introduce and develop important concepts. Key transferable skills will also be developed, including oral presentation and effective writing.
Course Delivery Information
|Not being delivered|
On completion of this course, the student will be able to:
- Basic understanding of the current concepts in inflammatory processes
- Attainment of advanced skills in reading and understanding the primary literature
- Development of scientific problem solving skills
- Development of oral presentation skills
|1: Davies LC, Jenkins SJ, Allen JE, Taylor PR. Tissue-resident macrophages. Nat Immunol. 2013 Oct;14(10):986-95.|
2: Poon IK, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 2014 Mar;14(3):166-80.
3: Novak ML, Thorp EB. Shedding light on impaired efferocytosis and nonresolving inflammation. Circ Res. 2013 Jun 21;113(1):9-12.
4: Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015 May;27(3):200-15.
5: Nourshargh S and Alon R. Leukocyte migration into inflamed tissue. Immunity 2014; 694-707
6: Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol. 2014 Mar;14(3):181-94.
|Graduate Attributes and Skills
|Keywords||Inflammation,Tissue repair,Leukocytes,Macrophages,Apoptosis,Inflammatory disease,Fibrosis
|Course organiser||Dr Rodger Duffin
Tel: 0131 242 6556
|Course secretary||Miss Rachel Allan
Tel: (0131 6)51 1514