Undergraduate Course: Living Materials and their Biomaterial Replacements 4 (MECE10016)
|School||School of Engineering
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Not available to visiting students
|Summary||The tissues that make up the human body display extraordinary characteristics; self-assembly, self-healing, adaptive and sometimes actuatable. This course looks into the source of these characteristics and then considers what materials we, as engineers, can use to replace them. We will focus attention on the musculoskeletal and cardiovascular systems of the body and the biomaterials that have been developed for use as substitutes. We'll consider how the body reacts to the presence of man-made biomaterials and the impact of the need for biomaterial sterilisation. Not all replacement materials are man-made; we'll think about tissue engineering as a way to grow new tissue. Finally, we'll introduce the legal processes surrounding regulation of biomaterial use and consider the ethics of growing new body parts.
The course will consist of 20 1-hour lectures and 10 1-hour example/Lab demonstration classes.
1. Soft materials and viscoelasticity. Linear and non-linear VE, time-dependent behaviours. An introduction to the living material.
2. Muscle - ultrastructure, passive v's contractile mechanical performance.
3. Connective tissues ligament and tendon, ultrastructure, mechanical properties, soft tissue healing.
4. Bone - cortical and cancellous ultrastructure, mechanical properties, bone healing.
5. Vascular tissue - Arteries veins and capillaries, smooth muscle, biomechanical behaviour, blood flow management.
6. Biocompatibilty - from clotting to the immune response.
7. Sterilisation techniques and aseptic approaches.
8. Metallic biomaterials - mechanical properties, corrosion, fretting and fatigue.
9. Polymeric biomaterials - mechanical properties, oxidative embrittlement and inertness v's biodegradability.
10. Ceramic biomaterials - mechanical properties, brittleness and surface engineering.
11. Tissue Engineering - pluripotent cells, scaffold materials and tissue constructs.
12. Regulation of biomaterials and ethical aspects.
They will include demonstration labs of tissues and anatomy.
Small coursework exercise [20%].
The course work will be an exercise looking at tissue understanding and anatomy.
3 questions on living materials and their biomaterial replacements [80%].
Course Delivery Information
|Academic year 2020/21, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 20,
Seminar/Tutorial Hours 10,
Feedback/Feedforward Hours 2,
Formative Assessment Hours 3,
Summative Assessment Hours 10,
Other Study Hours 35,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Additional Information (Learning and Teaching)
|Assessment (Further Info)
|Additional Information (Assessment)
||Coursework components will allow for feedback to be given. Also there will be a drop-in hour each to facilitate feedback.
||Hours & Minutes
|Main Exam Diet S1 (December)||2:00|
On completion of this course, the student will be able to:
- Understand the structure of human tissues and how this informs their mechanical properties. Appreciate the 'living' nature of tissue, its self-assembly maintenance and repair;
- Discuss the mechanical properties of metallic, ceramic and polymeric biomaterials and summarise the limitation of each of these classes of biomaterials. Reprise sterilisation technologies and their influence on biomaterial properties;
- Explain the concept of tissue engineering, its application and research directions;
- Understand blood clotting, biocompatibility and the body┐s reaction to foreign materials;
- Discuss the role of regulation and ethics in the use of biomaterials and tissue engineered materials.
|Fundamentals of Anatomy & Physiology, Global Edition, 2018 by Frederic H. Martini|
|Graduate Attributes and Skills
|Course organiser||Prof Alistair Elfick
Tel: (0131 6)50 7254
|Course secretary||Mr James Foster
Tel: (0131 6)51 3562