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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2021/2022

Information in the Degree Programme Tables may still be subject to change in response to Covid-19

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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 11 (Postgraduate)
Course typeOnline Distance Learning AvailabilityNot available to visiting students
SCQF Credits10 ECTS Credits5
Summary**Online Learning Course**

In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
Course description Not entered
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Course Delivery Information
Not being delivered
Learning Outcomes
On completion of this course, the student will be able to:
  1. Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
  2. Take an unknown model and test its reliability using software that tests its probity;
  3. Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
  4. Appreciate the concept of phase bias in electron density maps;
  5. Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
Reading List
None
Additional Information
Graduate Attributes and Skills Not entered
KeywordsSDDT
Contacts
Course organiserDr Paul McLaughlin
Tel: (0131 6)50 7060
Email: paul.mclaughlin@ed.ac.uk
Course secretaryMrs Claire Black
Tel: (0131 6)50 8637
Email: Claire.Black@ed.ac.uk
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