Postgraduate Course: Modelling Metabolic Pathways (PGBI11080)
Course Outline
School | School of Biological Sciences |
College | College of Science and Engineering |
Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Course type | Online Distance Learning |
Availability | Not available to visiting students |
SCQF Credits | 10 |
ECTS Credits | 5 |
Summary | **Online Learning Course**
All cells rely on a complex interacting network of numerous metabolic pathways. Each pathway in turn requires the concerted and well-regulated action of a team of enzymes. These pathways with their component enzymes frequently make attractive drug targets. Metabolic pathways in the parasitic protist Trypanosoma brucei (the causative agent of African sleeping sickness) will be used to illustrate how a combination of biochemical, genetic, control analysis and computer simulation approaches can be used to obtain useful working models of these pathways. |
Course description |
Not entered
|
Entry Requirements (not applicable to Visiting Students)
Pre-requisites |
|
Co-requisites | |
Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
Not being delivered |
Learning Outcomes
On completion of this course, the student will be able to:
- Appreciate the variability of metabolic status during different life stages of an organism.
- Determine control strengths of individual components of metabolic pathways under defined conditions.
- Model how changes in metabolite concentrations will affect flux through a pathway.
- Explain why particular enzyme components of a pathway may be better drug targets than others.
- Devise strategies to explore possible synergy effects when more than one enzyme is inhibited.
|
Additional Information
Graduate Attributes and Skills |
Not entered |
Keywords | MMP |
Contacts
Course organiser | Dr Paul Michels
Tel:
Email: Paul.Michels@ed.ac.uk |
Course secretary | Mrs Claire Black
Tel: (0131 6)50 8637
Email: Claire.Black@ed.ac.uk |
|
|