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DRPS : Course Catalogue : School of Chemistry : Chemistry

Undergraduate Course: Synthetic Organic Chemistry Level 10 (CHEM10024)

Course Outline
SchoolSchool of Chemistry CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 10 (Year 4 Undergraduate) AvailabilityAvailable to all students
SCQF Credits20 ECTS Credits10
SummaryA lecture course covering contemporary synthetic methods in organic chemistry, and their application to complex molecule synthesis. The course comprises individual lectures courses on: Template-directed Synthesis, Reagents for Organic Synthesis, Solid Phase Synthesis, Organometallics in Synthesis, Pericyclic Reactions and Asymmetric Base Catalysis. Either the Level 10 or Level 11 version of this course (as specified in the degree programme tables) is a compulsory requirement for Year 4/5 students on degrees in Chemistry or Medicinal and Biological Chemistry, but can be taken by Year 4/5 students on any Chemistry degree programme.
Course description The course contains the 6 lecture courses outlined above, each with an associated small group tutorial. The final examination consists of a total of six questions, one from each of the lecture modules. Students must answer 4 questions from these 6 options.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Students MUST have passed: Chemistry 3A (CHEM09005) AND Chemistry 3B (CHEM09006) AND Chemistry 3P Practical and Transferable Skills (CHEM09007)
Prohibited Combinations Students MUST NOT also be taking Synthetic Organic Chemistry Level 11 (CHEM11026)
Other requirements Must include a weighted average of Grade D or higher in Chemistry 3A and Chemistry 3B, at the first attempt; or with the permission of Head of School.
Information for Visiting Students
High Demand Course? Yes
Course Delivery Information
Not being delivered
Learning Outcomes
On completion of this course, the student will be able to:
  1. To recognise and understand the principles behind various pericyclic reactions, such as cycloadditions, electrocyclic reactions, sigmatropic rearrangements and group transfer reactions. To be able to use Frontier Molecular Orbital Theory (underpinned by the concept of Conservation of Orbital Symmetry) to analyze pericyclic reactions.
  2. To understand the chemistry and applications of a range of boron, phosphorus, silicon, sulfur and selenium reagents in modern organic synthesis. To appreciate and explain the use of organic and main-group nucleophilic catalysts, and how these can be applied to the construction of asymmetric organic molecules.
  3. To understand the use of solid phase organic methods as applied to peptide synthesis. To appreciate the role that solid phase organic synthesis plays in the pharmaceutical industry, particularly with respect to the use of combinatorial chemistry in screening against biological targets.
  4. To understand the principles and uses of modern organometallic methods in organic synthesis, including both stoichiometric and catalytic procedures.
  5. To understand the synthesis of topologically non-trivial and functional organic molecules using concepts from supramolecular chemistry. To be able to describe the principles behind molecular switches, motors, shuttles and other 'designer' molecules.
Reading List
"Organic Chemistry", Clayden, Greeves, Warren and Wothers, Oxford Press.
Additional reading material for each module will be provided by the course lecturer in lecture 1 of each course.
Additional Information
Graduate Attributes and Skills Not entered
Additional Class Delivery Information 30 hours lectures + 6 hours tutorials, at times arranged.
Course organiserDr Paul Lusby
Tel: (0131 6)50 4832
Course secretaryMr Craig Smith
Tel: (0131 6)50 4710
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