Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
|Course type||Online Distance Learning
||Availability||Not available to visiting students
|Summary||**Online Learning Course**
In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Course Delivery Information
|Not being delivered|
On completion of this course, the student will be able to:
- Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
- Take an unknown model and test its reliability using software that tests its probity;
- Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
- Appreciate the concept of phase bias in electron density maps;
- Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
|Graduate Attributes and Skills
|Course organiser||Dr Paul McLaughlin
Tel: (0131 6)50 7060
|Course secretary||Mrs Claire Black
Tel: (0131 6)50 8637