Postgraduate Course: Biophysical Chemistry for MSc Biochemistry (PGBI11107)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Available to all students
|Summary||This course deals with the major principles of physics and chemistry that underlie the structures, dynamics and interactions of biological macromolecules. The lectures will detail the structures of biomacromolecules and will provide an overview of many modern biophysical techniques. The workshops will allow students to probe macromolecular structures and to explore how the techniques are applied to biological systems and drug discovery. Techniques covered will include NMR spectroscopy, circular dichroism, light scattering, fluorescence, mass spectrometry and surface plasmon resonance.
Weeks 1-3 Chemistry & Structure of Biomacromolecules
- including proteins, nucleic acids, lipids and carbohydrates
Weeks 4-10 Biophysical Characterisation
- theory and applications in Biology of a range of biophysical techniques
Entry Requirements (not applicable to Visiting Students)
||Other requirements|| None
Information for Visiting Students
|High Demand Course?
Course Delivery Information
|Academic year 2022/23, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 30,
Seminar/Tutorial Hours 10,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||One essay of 2,000 words on a topic to be agreed between the lecturing staff and the Course Organiser (worth 30%) and an in-course problem (worth 70%).
|No Exam Information
On completion of this course, the student will be able to:
- Have a good understanding of macromolecular structure, conformational changes, dynamics and interactions.
- Be able to use molecular graphics tools to analyse molecular structures.
- Be familiar with the basic theory and experimental aspects of several modern biophysical techniques and to explain how they can be applied to investigate molecular structure, size, conformation, stability and interactions
- Be able to make a critical interpretation of the relevant literature
- Be able to write a coherent, interesting and informative essay
|One or more of the following text books: (reading an occasional chapter)|
Biophysical Chemistry by A. Cooper, Royal Society of Chemistry 2011
Biophysical Chemistry, volumes 1-3 by C.R. Cantor and P.R. Schimmel, Freeman, 1980
Biophysical Techniques by I.D. Campbell, Oxford University Press, 2012
Physical Chemistry: Principles and Applications in Biological Sciences by I. Tinoco, K. Sauer, J.C. Wang and J.D. Puglisi, Prentice Hall, 2002
Principles of Physical Biochemistry by K.E. van Holde, W.C. Johnson and P.S. Ho, Prentice Hall, 1998.
|Graduate Attributes and Skills
|Course organiser||Dr Janice Bramham
Tel: (0131 6)50 4786
|Course secretary||Ms Andrea Nichol
Tel: (0131 6)50 8643