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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Protein Production for Therapeutic Discovery (Biochemistry) (BICH11010)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) AvailabilityNot available to visiting students
SCQF Credits10 ECTS Credits5
SummaryThis course focuses on modern therapeutic proteins/targets and modern streamlining protocols for protein production and will cover:
- methods for expression and purification of proteins
- type and configuration of instrumentation used in modern protein production
- practical considerations for writing methods on such equipment
- sample handing limitations in protein purification protocols
Course description In the development of new therapeutics, structure determination is vital part of the pipeline of discovery. This relies heavily on the supply of suitable high quality protein material. The automation and technological developments in the platforms utilised for structural determination - X-ray diffraction, NMR or Cryo-EM has miniaturised the process and increased the throughout, with less material. However, this has increased the need for the development of rapid, effective, and reproducible processes for the expression, purification of proteins and protein therapeutics.

The core methods and technologies being implemented for modern production and purification will be discussed and illustrated. The type and configuration of the instrumentation used in modern protein production labs will be discussed as well as the practical considerations for development of effective methods on such equipment. Real world examples will be used as exemplars for best practice in strategy development, with a focus on newer biologic molecule entities.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Students MUST NOT also be taking Protein Production for Therapeutic Discovery (PGBI11132)
Other requirements None
Course Delivery Information
Academic year 2023/24, Not available to visiting students (SS1) Quota:  10
Course Start Semester 1
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 100 ( Lecture Hours 4, Seminar/Tutorial Hours 4, Supervised Practical/Workshop/Studio Hours 9, Feedback/Feedforward Hours 1, Summative Assessment Hours 2, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 78 )
Assessment (Further Info) Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment) 100% in-course assessment:

40% Group presentation
30% Summary of the paper assigned for the presentation
30% Write-up of ProteinLab practical session
Feedback Individual, group and/or class verbal feedback, as appropriate. Individual/group written feedback on presentations and written assessments.
No Exam Information
Learning Outcomes
On completion of this course, the student will be able to:
  1. be familiar with all common methods of production, primary processing and purification of proteins.
  2. have the theoretical knowledge to start practical work with recombinant proteins.
  3. be familiar with a range of chromatographic and extraction techniques to purify and assess proteins.
  4. be able to analyse and assess the applicable methods and practical logistics of their sample/methodology in context of the changing experimental conditions and available equipment, compared to the ┬┐ideal method┬┐.
  5. be able to demonstrate ability to design and implement a multi-step purification protocol.
Reading List
Additional Information
Graduate Attributes and Skills Knowledge and understanding: key aspects of protein purification techniques.

Personal and intellectual autonomy: course requires extensive external reading and ability to integrate this material with taught material, and present it effectively.

Communication: students learn to communicate details of an experimental protocol through presentation.
KeywordsNot entered
Course organiserDr Martin Wear
Tel: (0131 6)50 7054
Course secretaryMiss Fionnuala Nidhonnabhain
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