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DRPS : Course Catalogue : Royal (Dick) School of Veterinary Studies : Veterinary Sciences

Postgraduate Course: Animal models and genomic modification for One Health Models of Disease (VESC11245)

Course Outline
SchoolRoyal (Dick) School of Veterinary Studies CollegeCollege of Medicine and Veterinary Medicine
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) AvailabilityNot available to visiting students
SCQF Credits20 ECTS Credits10
SummaryIn this course all students will undertake a range of practical classes introducing core techniques for genome modification, including CRISPR-Cas9 gene editing, sgRNA synthesis, cell transfection and FACS/con-focal microscopy. Students will also take a taught module on comparative animal models including concepts of natural, transgenic, and genome-edited animal models.
Course description The course will deliver an overview of many of the types of animal models available and explore their use in "One Health" bioscience as models for human and animal diseases in addition to hands-on experience of genome editing.

1. Carry out a post mortem examination of a body, including the ability to identify and sample the major tissues
2. Compare different methods for creating animal models in the laboratory
3. Understand pluripotent stem cell types and their origins
4. Investigate natural and transgenic animal models of disease
5. Carry out in vitro gene editing using CrispR/Cas9
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Course Delivery Information
Academic year 2023/24, Not available to visiting students (SS1) Quota:  None
Course Start Semester 1
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 200 ( Seminar/Tutorial Hours 33, Supervised Practical/Workshop/Studio Hours 55, Feedback/Feedforward Hours 1, Summative Assessment Hours 1, Programme Level Learning and Teaching Hours 4, Directed Learning and Independent Learning Hours 106 )
Assessment (Further Info) Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment) This course will be assessed by written reports and oral presentation based on material delivered in laboratory practicals and lecture-based sessions:

75%: 2500-word essay on critical assessment of animal models
25%: Oral presentation on applications of practical aspects of course
Feedback Students will be given written feedback on their reports.
No Exam Information
Learning Outcomes
On completion of this course, the student will be able to:
  1. Demonstrate knowledge of mammalian, bird and fish anatomy and physiology
  2. Demonstrate the ability to carry out a post mortem examination and identify major organ systems and tissues and take appropriate samples for downstream investigations
  3. Have a comprehensive knowledge of modern uses of animal models including natural as well as engineered models
  4. Critically appraise literature on an animal model of human disease
  5. Demonstrate an understanding of the theoretical basis and practical application of gene editing.
Reading List
Additional Information
Graduate Attributes and Skills Upon completion of this course students will have developed a wide range of Graduate Attributes and Skills that will contribute to their professional growth as a successful researchers and experts in their field.
Through exposure to world-leading research they will be innovative and lifelong learners
They will use their skills in research and enquiry to identify and creatively tackle problems, and to seek out opportunities for learning.
KeywordsOne Health,genome modification,gene editing,mutagenesis,CRISPR/Cas9,animal handling
Course organiserDr Gerry McLachlan
Tel: (0131 6)51 9155
Course secretaryMiss Jennifer Hurst
Tel: (0131 6)51 3685
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