Postgraduate Course: Inflammation : Basic Principles (LISC11077)
Course Outline
| School |
School of Clinical Sciences and Community Health |
College |
College of Medicine and Veterinary Medicine |
| Course type |
Standard |
Availability |
Not available to visiting students |
| Credit level (Normal year taken) |
SCQF Level 11 (Postgraduate) |
Credits |
40 |
| Home subject area |
Life Sciences |
Other subject area |
None |
| Course website |
None
|
Taught in Gaelic? |
No |
| Course description |
This course provides training in the cellular and molecular events that underlie the development, progression and resolution of inflammatory responses. The major topics covered include (a) Initiation of inflammatory responses, (b) Regulation of inflammation and (c) Repair and resolution. The principal cell types involved in inflammation and control of their function by inflammatory mediators, chemokines and cytokines will be considered. Innate immune effector mechanisms and tissue repair mechanisms will be discussed, with particular emphasis on restoration of normal tissue function. The course will have a combination of seminar-based teaching and student-led moderated discussion sessions to develop the main teaching themes. |
Entry Requirements
| Pre-requisites |
|
Co-requisites |
|
| Prohibited Combinations |
|
Other requirements |
None
|
| Additional Costs |
None |
Course Delivery Information
| Not being delivered |
Summary of Intended Learning Outcomes
To provide a thorough background to the basic principles of inflammatory processes.
The course is as an elective research theme for the MSc Biomedical Sciences Programme to provide students with the opportunity to acquire relevant research skills and associated generic/transferable skills,.
The course will provide students with thorough and specific preparation for 3 year PhD training in Biomedical Sciences at MSc and en route to the PhD |
Assessment Information
| 100% laboratory project write up |
Special Arrangements
| None |
Additional Information
| Academic description |
Not entered |
| Syllabus |
Topics to be covered:
1) Haematopoiesis
2) Sentinel immune cells
T Lymphocytes
B Lymphocytes
3) Dialogue between Innate and Acquired immunity
Antigen presentation and autoimmunity
4) Lipid mediators of inflammation
5) Complement and complement regulators -
6) The acute phase response
7) Inflammatory Cytokines IL-1,IL-6, TNF
TGF-beta, IL-10
8) Host defence peptides
9) Recruitment of Inflammatory Cells
Phagocytosis
Reactive oxygen intermediate production
10) Apoptosis and Resolution of Inflammation
11) Fibroblast and stromal cell interactions
Extracellular matrix remodelling (MMPs TIMPs)
|
| Transferable skills |
Not entered |
| Reading list |
General reviews
Cell, 2010 Issue 140 volume 6
Is all about inflammation!
Innate immunity: quo vadis?
Medzhitov R.
Nat Immunol. 2010 Jul;11(7):551-3. No abstract available
Adhesion and migration
Getting to the site of inflammation: the leukocyte adhesion cascade updated.
Ley K, Laudanna C, Cybulsky MI, Nourshargh S.
Nat Rev Immunol. 2007 Sep;7(9):678-89. Review.
Phagocytosis
How human neutrophils kill and degrade microbes: an integrated view.
Nauseef WM.
Immunol Rev. 2007 Oct;219:88-102. Review.
Signalling and transcriptional control
Transcriptional control of the inflammatory response.
Medzhitov R, Horng T
Nat Rev Immunol. 2009 Oct;9(10):692-703.
Chemokines
Chemokines: multiple levels of leukocyte migration control.
Moser B, Wolf M, Walz A, Loetscher P
Trends Immunol. 2004 Feb;25(2):75-84.
Neutrophil:
Neutrophils and immunity: challenges and opportunities.
Nathan C.
Nat Rev Immunol. 2006 Mar;6(3):173-82. Review.
Mast cell
Frossi B, De Carli M, Pucillo C.
The mast cell: an antenna of the microenvironment that directs the immune response. J Leukoc Biol. 2004 Apr;75(4):579-85. Epub 2004 Jan 14. Review.
Monocyte/ Macrophage
Mosser DM, Edwards JP
Nat Rev Immunol. 2008 Dec;8(12):958-69.
Exploring the full spectrum of macrophage activation.
Mediators
Anti-inflammatory Agents: Present and Future.
Dinarello CA.
Cell. 2010 Mar 19;140(6):935-50.
Apoptosis
Pharmacological manipulation of granulocyte apoptosis: potential therapeutic
targets.
Ward C, Dransfield I, Chilvers ER, Haslett C, Rossi AG.
Trends Pharmacol Sci. 1999 Dec;20(12):503-9. Review.
Resolution of Inflammation
A blast from the past: clearance of apoptotic cells regulates immune responses.
Savill J, Dransfield I, Gregory C, Haslett C.
Nat Rev Immunol. 2002 Dec;2(12):965-75. Review.
Non- Resolving Inflammation
Nathan and Ding
Cell, 2010 140 871-882
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| Study Abroad |
Not entered |
| Study Pattern |
2 x 2hour seminar/discussion sessions
Laboratory practical project
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| Keywords |
Inflammation, Inflammatory cells, Cytokines, Initiation, Repair, Resolution |
Contacts
| Course organiser |
Dr Ian Dransfield
Tel: (0131 6)50 6948
Email: I.Dransfield@ed.ac.uk |
Course secretary |
Mrs Marie Manson
Tel: 0131 242 6478
Email: Marie.Manson@ed.ac.uk |
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