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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2015/2016

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DRPS : Course Catalogue : School of Biological Sciences : Biochemistry

Undergraduate Course: Structural Biology (BICH10007)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 10 (Year 4 Undergraduate) AvailabilityAvailable to all students
SCQF Credits10 ECTS Credits5
SummaryStructural biology illuminates how biological molecules and macromolecular complexes are able to carry out their functions: in other words, it allows us to find out how proteins actually work at a molecular level. The aim of this course is to enrich your understanding of structural molecular biology by considering ┐the life-cycle of a protein┐. We build on knowledge gained in SFP3, and the first two sessions will incorporate clicker based revision sessions along with some introductory material on protein and nucleic acid structures.

The lecture programme begins in the DNA world, where we consider protein evolution, domain conservation and how DNA is metabolised (i.e. moved, repaired and replicated). After DNA is transcribed and translated, we consider how nascent protein sequences are folded. We will also look at the roles of natively unstructured proteins. In the protein world information is transmitted by interactions between molecules. In this context we will consider the protein-protein interactions underpinning accurate control of cell division, as well as protein-carbohydrate interactions involved in disease, and the exploitation of these in drug discovery. Finally we will consider how post-translational modifications of proteins can be detected and how they can enhance or alter a protein┐s function
Course description Not entered
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Students MUST have passed: Structures and Functions of Proteins 3 (BILG09015)
Co-requisites
Prohibited Combinations Other requirements None
Additional Costs Notepads
Information for Visiting Students
Pre-requisitesNone
High Demand Course? Yes
Course Delivery Information
Academic year 2015/16, Available to all students (SV1) Quota:  None
Course Start Semester 1
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 100 ( Lecture Hours 18, Dissertation/Project Supervision Hours 3, Supervised Practical/Workshop/Studio Hours 2, Summative Assessment Hours 2, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 73 )
Assessment (Further Info) Written Exam 100 %, Coursework 0 %, Practical Exam 0 %
Additional Information (Assessment) Exam
Feedback Not entered
Exam Information
Exam Diet Paper Name Hours & Minutes
Main Exam Diet S1 (December)Structural Biology2:00
Learning Outcomes
On completion of this course, the student will be able to:
  1. Understand the evolution of protein structural motifs and domains and associate this with function;
  2. Use on-line structural databases and tools to predict the properties, structure and function of proteins.
  3. Understand and explain enzyme mechanisms in a structural context.
  4. Describe mechanisms of protein folding and the roles of natively unstructured proteins in biology.
  5. Understand how cross-talk between proteins and post-translational protein modifications (e.g. phosphorylation, ubiquitination) facilitate information processing in cells.
Reading List
None
Additional Information
Graduate Attributes and Skills Not entered
KeywordsBIOCHEMStruc
Contacts
Course organiserDr Julia Richardson
Tel: (0131 6)50 7052
Email: julia.richardson@ed.ac.uk
Course secretaryMrs Linda Goodall
Tel: (0131 6)50 5521
Email: Linda.Goodall@ed.ac.uk
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