Undergraduate Course: Structural Biology (BICH10007)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 10 (Year 4 Undergraduate)
||Availability||Available to all students
|Summary||Structural biology illuminates how biological molecules and macromolecular complexes are able to carry out their functions: in other words, it allows us to find out how proteins actually work at a molecular level. The aim of this course is to enrich your understanding of structural molecular biology by considering ┐the life-cycle of a protein┐. We build on knowledge gained in SFP3, and the first two sessions will incorporate clicker based revision sessions along with some introductory material on protein and nucleic acid structures.
The lecture programme begins in the DNA world, where we consider protein evolution, domain conservation and how DNA is metabolised (i.e. moved, repaired and replicated). After DNA is transcribed and translated, we consider how nascent protein sequences are folded. We will also look at the roles of natively unstructured proteins. In the protein world information is transmitted by interactions between molecules. In this context we will consider the protein-protein interactions underpinning accurate control of cell division, as well as protein-carbohydrate interactions involved in disease, and the exploitation of these in drug discovery. Finally we will consider how post-translational modifications of proteins can be detected and how they can enhance or alter a protein┐s function
Information for Visiting Students
|High Demand Course?
Course Delivery Information
|Academic year 2015/16, Available to all students (SV1)
|Learning and Teaching activities (Further Info)
Lecture Hours 18,
Dissertation/Project Supervision Hours 3,
Supervised Practical/Workshop/Studio Hours 2,
Summative Assessment Hours 2,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||Hours & Minutes
|Main Exam Diet S1 (December)||Structural Biology||2:00|
On completion of this course, the student will be able to:
- Understand the evolution of protein structural motifs and domains and associate this with function;
- Use on-line structural databases and tools to predict the properties, structure and function of proteins.
- Understand and explain enzyme mechanisms in a structural context.
- Describe mechanisms of protein folding and the roles of natively unstructured proteins in biology.
- Understand how cross-talk between proteins and post-translational protein modifications (e.g. phosphorylation, ubiquitination) facilitate information processing in cells.
|Graduate Attributes and Skills
|Course organiser||Dr Julia Richardson
Tel: (0131 6)50 7052
|Course secretary||Mrs Linda Goodall
Tel: (0131 6)50 5521
© Copyright 2015 The University of Edinburgh - 18 January 2016 3:30 am