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DEGREE REGULATIONS & PROGRAMMES OF STUDY 2015/2016

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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Structure Determination of Drug Targets (PGBI11070)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) AvailabilityNot available to visiting students
SCQF Credits10 ECTS Credits5
Summary**Online Distance Learning Course**

In Drug Discovery that has a rationale basis a three-dimensional structure of the target is a necessity. Students need an appreciation of X-ray crystallography to be able to evaluate critically their credence in crystallographic models used in this work.
This course will lead students through the process, illustrating the criteria for reliable models and the sometimes subtle hints that others are wrong in detail, while a few are grossly wrong through naivety or fraud.
Course description Not entered
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites
Prohibited Combinations Other requirements None
Course Delivery Information
Academic year 2015/16, Not available to visiting students (SS1) Quota:  None
Course Start Semester 2
Course Start Date 15/02/2016
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 100 ( Online Activities 20, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 78 )
Assessment (Further Info) Written Exam 0 %, Coursework 100 %, Practical Exam 0 %
Additional Information (Assessment) 50% = Group Assessment (including maximum 20% variation for Peer Assessment of contribution)

50% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
Feedback Not entered
No Exam Information
Learning Outcomes
At the end of this course students should be able to:

Read a x-ray crystallography paper with an appreciation of the methods and the reliability of the model;
Take an unknown model and test its reliability using software that tests its probity;
Acquire advanced knowledge of correct protein stereochemistry as a measure of reliability;
Appreciate the concept of phase bias in electron density maps;
Demonstrate a knowledge of what can be expected of a crystallographic model determined at any particular resolution.
Reading List
None
Additional Information
Graduate Attributes and Skills Not entered
KeywordsSDDT
Contacts
Course organiserDr Paul Mclaughlin
Tel: (0131 6)50 7060
Email: paul.mclaughlin@ed.ac.uk
Course secretaryMiss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk
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