Postgraduate Course: Measuring Drug Binding (PGBI11071)
Course Outline
| School | School of Biological Sciences |
College | College of Science and Engineering |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 10 |
ECTS Credits | 5 |
| Summary | **Online Distance Learning Course**
A core competency in Drug Discovery is to appreciate how to measure drug binding quantitatively, in order to assess derivatives of a ¿lead¿ compound that bind more tightly. There are common pitfalls in the interpretation of these numbers, which are inadequately appreciated by many. The course is designed to introduce students to concepts and nomenclature in quantitating drug binding. A common technique involving fluorescence quenching will be used for illustration. Students will fit experimental data using a variety of models and use statistical techniques to distinguish between them. Concepts of over- and under-fitting data, and correlation of parameters will be illustrated, as well as confounding artefacts that affect biophysical techniques. |
| Course description |
Not entered
|
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
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| Academic year 2015/16, Not available to visiting students (SS1)
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Quota: None |
| Course Start |
Semester 1 |
| Course Start Date |
09/11/2015 |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
100
(
Online Activities 20,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
78 )
|
| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
|
| Additional Information (Assessment) |
50% = Group Assessment (including maximum 20% variation for Peer Assessment of contribution)
50% = Electronic Portfolio (comprising of learning log and contribution to skills profile)
|
| Feedback |
Not entered |
| No Exam Information |
Learning Outcomes
At the end of this course students should be able to:
¿ Demonstrate advanced knowledge of concepts applied to measuring drug binding;
¿ Acquire the ability to use common software to fit experimental data and to extend this into unknown situations;
¿ Show an appreciation of under- and over-fitting experimental data and be able to use statistical methods to demonstrate either;
¿ Show awareness in the literature of common pitfalls in measuring drug binding ;
¿ Have acquired a critical faculty regarding potential artifacts in biophysical techniques.
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Additional Information
| Graduate Attributes and Skills |
Not entered |
| Keywords | MDB |
Contacts
| Course organiser | Dr Paul Mclaughlin
Tel: (0131 6)50 7060
Email: paul.mclaughlin@ed.ac.uk |
Course secretary | Miss Vicky Mactaggart
Tel: (0131 6)51 7052
Email: Vicky.Mactaggart@ed.ac.uk |
|
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