Postgraduate Course: Cognitive Ageing and Cognitive Epidemiology (PSYL11048)
Course Outline
| School | School of Philosophy, Psychology and Language Sciences |
College | College of Humanities and Social Science |
| Credit level (Normal year taken) | SCQF Level 11 (Postgraduate) |
Availability | Not available to visiting students |
| SCQF Credits | 10 |
ECTS Credits | 5 |
| Summary | This course will provide an introduction to Cognitive Ageing and Cognitive Epidemiology. Cognitive ageing individual differences and experimental psychology approaches will be included. A wide range of determinants of cognitive ageing will be considered, informed by genetic and brain imaging studies and including medical (including endocrine), lifestyle and social effects. Relevant animal studies are considered. Cognitive epidemiology addresses the association between early life intelligence and morbidity and mortality. |
| Course description |
Topics included are:
Week 1
Course overview and cognitive ageing from an individual differences approach
Week 2
Human cognitive ageing: human cognitive neuroscience in normal and pathological ageing
Week 3
An introduction to cognitive epidemiology
Week 4
Mechanisms of cognitive ageing: human/translation work and animal models
Week 5
Methodological underpinnings of the work in cognitive ageing and cognitive epidemiology
Week 6
Feedback event: Assessment preparation/information session
|
Entry Requirements (not applicable to Visiting Students)
| Pre-requisites |
|
Co-requisites | |
| Prohibited Combinations | |
Other requirements | None |
Course Delivery Information
|
| Academic year 2015/16, Not available to visiting students (SS1)
|
Quota: None |
| Course Start |
Block 1 (Sem 1) |
Timetable |
Timetable |
| Learning and Teaching activities (Further Info) |
Total Hours:
100
(
Lecture Hours 10,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
88 )
|
| Assessment (Further Info) |
Written Exam
0 %,
Coursework
100 %,
Practical Exam
0 %
|
| Additional Information (Assessment) |
1) Critique of a published paper (1500 words). Students will select from a list of 8 published research papers provided by course lecturers, and produce a written critique. Further instructions will be given on structure and content of the critique.
2) Research proposal (1500 words). Students will be asked to write part of a research proposal suitable for an application for research funding. This will be based on a topic within one of the lectures and can be for either a new study or secondary analysis of an existing dataset.
Assignment deadline: Thursday 3rd December 2015, 12 noon
Word limit: 10% leeway on the word limit
Return deadline: 15th January 2016 |
| Feedback |
Assessment preparation and information session held. Comments provided on submitted assessments. |
| No Exam Information |
Learning Outcomes
On completion of this course, the student will be able to:
- Demonstrate an advanced understanding of the phenomena of cognitive ageing and cognitive epidemiology
- Critically evaluate studies examining the determinants of cognitive ageing in humans and animals
- Critically evaluate studies in the field of cognitive epidemiology
- Understand and apply the research methods of psychology (including individual differences and experimental psychology) and epidemiology to cognitive ageing and cognitive epidemiology
- Consider pursuing a topic in cognitive ageing and cognitive epidemiology in more detail for the course essay
|
Reading List
Barulli, D., & Stern, Y. (2013). Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve. Trends in Cognitive Sciences, 17, 502-509.
Deary, I.J. (2014). The stability of intelligence from childhood to old age. Current Directions in Psychological Science, 23, 239-245.
Deary, I.J. (2013). Intelligence. Current Biology, 23, R673-R676.
Deary, I.J., Corley, J., Gow, A.J., Harris, S.E., Houlihan, L.M., Marioni, R.E., Penke, L., Rafnsson, S.B., & Starr, J.M. (2009). Age-associated cognitive decline. British Medical Bulletin, 92, 135-152.
Hedden, T., & Gabrieli, J. D. E. (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nature Reviews Neuroscience, 5, 87-96.
Plassman, B.L., Williams, J.W., Burke, J.R., Holsinger, T., & Benjamin, S. (2010). Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Annals of Internal Medicine, 153, 182-193.
Salthouse, T.A. (2004). Localizing age-related individual differences in a hierarchical structure. Intelligence, 32, 541-561.
Salthouse, T.A. (2010). Major Issues in Cognitive Ageing. Oxford: Oxford University Press. (Especially chapter 1).
Salthouse, T. A. (2014). Why are there different age relations in cross-sectional and longitudinal comparisons of cognitive functioning? Current Directions in Psychological Science, 23, 252-256.
Wilson, R.S. (2002). Individual differences in rates of change in cognitive abilities of older persons. Psychology and Aging, 17, 179-193.
Craig, F. I. M., & Bialystok, E. (2006). Planning and task management in older adults: cooking breakfast. Memory and Cognition, 34(6), 1236-1249.
Hunter, E.M., Phillips, L.H., & MacPherson, S.E. (2010). Effects of age on cross-modal emotion perception. Psychology and Aging, 25(4), 779-787.
Logie, R.H. & Maylor, E.A. (2009). An internet study of prospective memory across adulthood. Psychology and Aging, 24(3), 767-774.
Kaschel, R., Logie, R.H., Kazén, M & Della Sala, S. (2009). Alzheimer's disease, but not ageing or chronic depression, affects dual-tasking. Journal of Neurology, 256, 1860-1868.
MacPherson, S.E., Phillips, L.H. & Della Sala, S. (2002). Age, executive function and social decision-making: a dorsolateral prefrontal theory of cognitive aging. Psychology and Aging, 17(4), 598-609.
McGurn, B., Starr, J.M., Topfer, J.A., Pattie, A., Whiteman, M.C., Lemmon, H.A., Whalley, L.J., & Deary, I.J. (2004). Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation. Neurology, 62, 1184-1186.
Starr, J.M., & Lonie, J. (2007). Relationship between behavioural and psychological symptoms of dementia and cognition in Alzheimer disease. Dementia and Geriatric Cognitive Disorders, 24, 343-347.
Starr, J.M., & Lonie, J. (2008). Estimates of pre-morbid IQ effects on cognitive and functional outcomes in Alzheimer disease: a longitudinal study in a treated cohort. BMC Psychiatry, 8, 27.
Deary, I.J., & Batty, G.D. (2007). Cognitive epidemiology: a glossary of terms. Journal of Epidemiology and Community Health, 61, 378-84.
Calvin, C.M., Deary, I.J., Fenton, C., Roberts, B.A., Der, G., Leckenby, N.,
Batty, G.D. (2011). Intelligence in youth and all-cause-mortality: systematic review with meta-analysis. International Journal of Epidemiology, 40 (3), 626-644.
Batty, G.D., Shipley, M., Mortensen, L., Boyle, S., Barefoot, J., Gronbaek, M., Gale, C., & Deary, I.J. (2008). IQ in late adolescence/early adulthood, risk factors in middle-age, and later all-cause mortality in men: the Vietnam Experience Study. Journal of Epidemiology and Community Health, 62, 522-31.
Batty, G. D., Wennerstad, K. M. et al. (2009) IQ in early adulthood and mortality by middle age: cohort study of 1 million Swedish men. Epidemiology, 20,100-109.
Der, G., Batty, G. D., & Deary, I. J.(2009) The association between IQ in adolescence and a range of health outcomes at 40 in the 1979 US National Longitudinal Study of Youth. Intelligence, 37, 573-580.
Batty, G. D., Gale, C. R., Tynelius, P., Deary, I. J., & Rasmussen, F. (2009) IQ in early adulthood, socioeconomic position, and unintentional injury mortality by middle age: a cohort study of more than 1 million Swedish men. American Journal of Epidemiology, 169, 606-15.
Gale, C. R., Batty, G. D., Tynelius, P., Deary, I. J., & Rasmussen, F. (2010) Intelligence in early adulthood and subsequent hospitalization for mental disorders. Epidemiology, 21, 70-77.
Koenen, K. C., Moffitt, T. E., Roberts, A. L., Martin, L. T., Kubzansky, L., Harrington, H., Poulton, R., & Caspi, A. (2009) Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. American Journal of Psychiatry, 166, 50-57
Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., de Kloet, E. R., Lightman, S. L., Lupien, S. J., Roozendaal, B., & Seckl, J. R. (2006). Do corticosteroids damage the brain? Journal of Neuroendocrinology, 18, 393-411.
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience, 10, 434-445.
Sooy, K., Webster, S. P., Noble, J., Binnie, M., Walker, B. R., Seckl, J. R., &
Yau, J. L. W. (2010). Partial deficiency or short-term inhibition of 11¿-hydroxysteroid dehydrogenase type 1 improves cognitive function in ageing mice. Journal of Neurosci 30, 13867 - 13872.
Yau, J. L., & Seckl, J. R. (20120. Local amplification of glucocorticoids in the aging brain and impaired spatial memory. Frontiers in Aging Neuroscience 4, 24.
Cape, E., Hall, R. J., van Munster, B. C., de Vries, A., Howie, S. E., Pearson, A., Middleton, S. D., Gillies, F., Armstrong, I. R., White, T. O., Cunningham, C., de Rooij, S. E., & MacLullich, A. M. (2014). Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1¿ in delirium after hip fracture. Journal of Psychosomatic Research, 77(3), 219-225.
Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., Cunningham, C., Polvikoski, T., Sulkava, R., MacLullich, A. M., & Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain, 135(9), 2809-16.
MacLullich, A. M., Anand, A., Davis, D. H., Jackson, T., Barugh, A. J., Hall, R. J., Ferguson, K. J., Meagher, D. J., & Cunningham, C. (2013). New horizons in the pathogenesis, assessment and management of delirium. Age Ageing, 42(6), 667-74. (Review)
Inouye, S. K., Westendorp, R. G., & Saczynski, J. S. (2014). Delirium in elderly people. Lancet,
383(9920), 911-22. (Review)
Deary, I.J., Johnson, W., & Houlihan, L.M. (2009). Genetic foundations of human intelligence. Human Genetics, 126, 215-232. doi: 10.1007/s00439-009-0655-4.
Payton, A. (2009). The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009. Neuropsychological Review, 19, 451-477. doi: 10.1007/s11065-009-9116-z.
Harris, S. E., & Deary I. J. (2011). The genetics of cognitive ability and cognitive ageing in healthy older people. Trends in Cognitive Sciences, 15, 388-394. doi:10.1016/j.tics.2011.07.004.
Davies, G., Tenesa, A., Payton, A., Yang, J., Harris, S. E., Liewald, D., Ke, X., Le Hellard, S., Chistoforou, A., Luciano, M., McGhee, K., Lopez, L. M., Gow, A. J., Corley, J., Redmond, P., Fox, H. C., Haggarty, P., Whalley, L. J., McNeill, G., Goddard, M. E., Espeseth, T., Lundervold, A. J., Reinvang, I., Pickles, A., Steen, V. M., Ollier, W., Portoeus, D. J., Horan, M., Starr, J. M., Pendleton, N., Visscher, P. M., & Deary, I. J. (2011). Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry, 16, 996-1005. doi:10.1038/mp.2011.85.
Davies, G., Harris, S. E., Reynolds, C. A., Payton, A., Knight, H. M., Liewald, D. C., Lopez, L. M., Luciano, M., Gow, A. J., Corley, J., Henderson, R., Murray, C., Pattie, A., Fox, H. C., Redmond, P., Lutz, M. W., Chiba-Falek, O., Linnertz, C., Saith, S., Haggarty, P., McNeill, G., Ke, X., Ollier, W., Horan, M., Roses, A. D., Ponting, C. P., Porteous, D. J., Tenesa, A., Pickles, A., Starr, J. M., Whalley, L. J., Pedersen, N. L., Pendleton, N., Visscher, P. M., & Deary, I. J. (2014). A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Molecular Psychiatry, 19(1), 76-87. doi: 10.1038/mp.2012.159.
Harris, S. E., et al. (2014). Polygenic risk for Alzheimer¿s disease is not associated with cognitive ability or cognitive aging in non-demented older people. Journal of Alzheimer¿s Disease, 39(3), 565-74. doi:10.3233/JAD-131058.
Madden, D. J., Bennett, I. J., Burzynska, A., Potter, G. G., Chen, N. K., & Song, A.W. (2012). Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochimica et Biophysica Acta, 1822(3), 386-400.
Penke, L., Maniega, S. M., Bastin, M. E., Valdés Hernández, M. C., Murray, C., Royle, N. A., Starr, J. M., Wardlaw, J. M., & Deary, I. J. (2012). Brain white matter tract integrity as a neural foundation for general intelligence. Molecular Psychiatry, 17(10), 1026-30.
Karama, S., Bastin, M. E., Murray, C., Royle, N. A., Penke, L., Muñoz Maniega, S., Gow, A. J., Corley, J., Valdés Hernández, M., Lewis, J. D., Rousseau, M. E., Lepage, C., Fonov, V., Collins, D. L., Booth, T., Rioux, P., Sherif, T., Adalat, R., Starr, J. M., Evans, A. C., Wardlaw, J. M., & Deary, I. J. (2014). Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age. Molecular Psychiatry, 19(5), 555-559. doi: 10.1038/mp.2013.64 |
Additional Information
| Graduate Attributes and Skills |
Not entered |
| Additional Class Delivery Information |
Attend all lectures as scheduled |
| Keywords | Intelligence,Memory,Ageing,Epidemiology,Individual differences,Information processing,Neuroend |
Contacts
| Course organiser | Prof Ian Deary
Tel: (0131 6)50 3452
Email: I.Deary@ed.ac.uk |
Course secretary | Miss Toni Noble
Tel: (0131 6)51 3188
Email: Toni.noble@ed.ac.uk |
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