Postgraduate Course: Protein Molecular Modelling Practical Skills (PGBI11111)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||During a typical molecular modelling project a protein structure might be modelled by homology modelling, its motions simulated by molecular dynamics and possible inhibitors discovered by virtual screening. This course will look in detail at these techniques, and the students will be given practical experience of them within a typical molecular modelling computational environment
Week 1 lecture Template structure selection for homology modelling/introduction to accompanying practical session
Week 2 Practical session on template selection
Week 3 introduction to Essay assignment, example paper analysis
Week 4 Homology model construction and validation
Week 5 Practical session concentrating on validation
Week 6 Model preparation for molecular dynamics
Week 7 practical session on preparing structure and starting dynamics run
Week 8 Dynamics trajectory analysis and validation
Week 9 Virtual screening methods.
Week 10 Scoring methods in virtual screening.
Course Delivery Information
|Not being delivered|
On completion of this course, the student will be able to:
- On successful completion of the course, students should be able to demonstrate an understanding of the technologies that underpin the three featured techniques.
- Students should also have demonstrated the ability to successfully complete and critically analyse the results from these techniques.
|Graduate Attributes and Skills
||Enhanced computing skills
|Course organiser||Dr Paul Taylor
Tel: (0131 6)50 7058
|Course secretary||Ms Andrea Nichol
Tel: (0131 6)50 8643