Postgraduate Course: Genetics of Human Complex Traits (PGBI11083)
|School||School of Biological Sciences
||College||College of Science and Engineering
|Credit level (Normal year taken)||SCQF Level 11 (Postgraduate)
||Availability||Not available to visiting students
|Summary||This course focuses on genetic and genomic approaches appropriate for the study of human populations. The course will emphasise analysis of both genetic disorder, and complex traits within the normal ranges and in the context of disease. It will identify the practical aspects
associated with such analyses in human populations due to the structure and organisation of the human population and the importance of late-onset-disorders.
1 Introduction to complex traits and how to identify a disorder with a genetic component.
2 Human population diversity, population stratification & admixture.
3 Genetic testing & screening, Bayesian risk prediction.
4 Linkage analysis I: Quantitative traits. Extended families, nuclear families,phenotype definition, confounders.
5 Linkage analysis II: Genetic disorders. Diagnosis, liability classes, penetrance,heterogeneity. Strategies for late-onset diseases.
6 Association studies, design, confounders, familial versus sporadic, endophenotypes.
7 Genome-wide association studies of quantitative traits in healthy populations and in the context of disease, regional/genome-wide prediction.
8 Genome-wide association studies of genetic disorders (case:control) identifying genes for complex genetic disorders, computational and bioinformatic tools.
9 Machine Learning. UK Biobank. Animal Models: ENUmutagenesis, knockouts, conditional knockouts.
10 Animal Models: ENU mutagenesis, transcriptomics and proeomics - high throughput methodologies, Epistasis, gene expression, protein interactions, pathway analysis.
Course Delivery Information
|Academic year 2018/19, Not available to visiting students (SS1)
|Learning and Teaching activities (Further Info)
Lecture Hours 24,
Supervised Practical/Workshop/Studio Hours 6,
Programme Level Learning and Teaching Hours 2,
Directed Learning and Independent Learning Hours
|Assessment (Further Info)
|Additional Information (Assessment)
||One centrally arranged exam (60%) plus one assignment (40%)
||Hours & Minutes
|Main Exam Diet S2 (April/May)||Genetics of Human Complex Traits||1:30|
| On successfully completing the course, students will be able to demonstrate an understanding of the practical application of genomics and genome analysis to the analysis of human populations and genetic disorders. They will be conversant with inherent difficulties and opportunities facing such analyses, and the multiple approaches that have been implemented. They will be conversant with the integration of multiple genome-wide approaches and the value of genetic models.
|Graduate Attributes and Skills
|Course organiser||Dr Jacob Moorad
Tel: (0131 6)50 5442
|Course secretary||Mrs Jennifer Morris
Tel: (0131 6)50 5513