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DRPS : Course Catalogue : School of Biological Sciences : Postgraduate

Postgraduate Course: Genetics of Human Complex Traits (PGBI11083)

Course Outline
SchoolSchool of Biological Sciences CollegeCollege of Science and Engineering
Credit level (Normal year taken)SCQF Level 11 (Postgraduate) AvailabilityNot available to visiting students
SCQF Credits10 ECTS Credits5
SummaryThis course focuses on genetic and genomic approaches appropriate for the study of human populations. The course will emphasise analysis of both genetic disorder, and complex traits within the normal ranges and in the context of disease. It will identify the practical aspects
associated with such analyses in human populations due to the structure and organisation of the human population and the importance of late-onset-disorders.
Course description Session Topic
1 Introduction to complex traits and how to identify a disorder with a genetic component.
2 Human population diversity, population stratification & admixture.
3 Genetic testing & screening, Bayesian risk prediction.
4 Linkage analysis I: Quantitative traits. Extended families, nuclear families,phenotype definition, confounders.
5 Linkage analysis II: Genetic disorders. Diagnosis, liability classes, penetrance,heterogeneity. Strategies for late-onset diseases.
6 Association studies, design, confounders, familial versus sporadic, endophenotypes.
7 Genome-wide association studies of quantitative traits in healthy populations and in the context of disease, regional/genome-wide prediction.
8 Genome-wide association studies of genetic disorders (case:control) identifying genes for complex genetic disorders, computational and bioinformatic tools.
9 Machine Learning. UK Biobank. Animal Models: ENUmutagenesis, knockouts, conditional knockouts.
10 Animal Models: ENU mutagenesis, transcriptomics and proeomics - high throughput methodologies, Epistasis, gene expression, protein interactions, pathway analysis.
Entry Requirements (not applicable to Visiting Students)
Pre-requisites Co-requisites Students MUST also take: Population and Quantitative Genetics (PGBI11001)
Students MUST also take: Quantitative Genetic Models (PGBI11085) AND Linkage and Association in Genome Analysis (PGBI11086)
Prohibited Combinations Other requirements None
Course Delivery Information
Academic year 2018/19, Not available to visiting students (SS1) Quota:  None
Course Start Semester 2
Timetable Timetable
Learning and Teaching activities (Further Info) Total Hours: 100 ( Lecture Hours 24, Supervised Practical/Workshop/Studio Hours 6, Programme Level Learning and Teaching Hours 2, Directed Learning and Independent Learning Hours 68 )
Assessment (Further Info) Written Exam 50 %, Coursework 50 %, Practical Exam 0 %
Additional Information (Assessment) One centrally arranged exam (60%) plus one assignment (40%)
Feedback Not entered
Exam Information
Exam Diet Paper Name Hours & Minutes
Main Exam Diet S2 (April/May)Genetics of Human Complex Traits1:30
Learning Outcomes
On successfully completing the course, students will be able to demonstrate an understanding of the practical application of genomics and genome analysis to the analysis of human populations and genetic disorders. They will be conversant with inherent difficulties and opportunities facing such analyses, and the multiple approaches that have been implemented. They will be conversant with the integration of multiple genome-wide approaches and the value of genetic models.
Reading List
Additional Information
Graduate Attributes and Skills Not entered
Course organiserDr Jacob Moorad
Tel: (0131 6)50 5442
Course secretaryMrs Jennifer Morris
Tel: (0131 6)50 5513
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